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Vav2 Gene Detail
 Symbol
Name
ID
Vav2
vav 2 oncogene
MGI:102718


Nomenclature History
Synonyms 2810040F13Rik
Genetic Map
Chromosome 2
15.3 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 9)

Sequence Map
Chr2:27117624-27282553 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Vav2 ± 2 cM)
Protein SuperFamily: vav transforming protein
TreeFam: TF316171
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000012034 VEGA Gene Model | MGI Sequence Detail 164930 C57BL/6J ± Kb
transcript NM_009500 RefSeq | MGI Sequence Detail 3498 C57BL/6
polypeptide Q60992 UniProt | EBI | MGI Sequence Detail 868 Not Applicable
For the selected sequences
All sequences(20)
Alleles
and
phenotypes
All alleles(11) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(9)
Homozygous null mutants have defects in humoral immune response to type II thymus-independent antigens, in primary response to thymus-dependent antigens and inability to switch immunoglobulin class, form germinal centers and generate secondary responses.
Polymorphisms RFLP(2) SNPs within 2kb(829 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process angiogenesis, cell migration...
Component cytoplasm, intracellular...
Function epidermal growth factor receptor binding, guanyl-nucleotide exchange factor activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (1)    Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23,28
  Assay Type Assays   Results
      RT-PCR 1   46
cDNA source data(103)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(107) Genomic(2) cDNA(103) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000009621
DoTS DT.101393406, DT.50315927
Consensus CDS Project CCDS15827.1
UniGene 179011
DFCI TC1577637, TC1587139
NIA Mouse Gene Index U022442
Entrez Gene 22325
VEGA Gene Model OTTMUSG00000012034
International Mouse Knockout Project Status Vav2
Protein
domains
InterPro ID Description
IPR000219 Dbl homology (DH) domain
IPR000980 SH2 motif
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
IPR001452 Src homology-3 domain
IPR001715 Calponin-like actin-binding
IPR001849 Pleckstrin homology
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR011511 Variant SH3
IPR016146 Calponin-homology
IPR020473 Src homology-3, region
Graphical View of Protein Domain Structure
References
(Earliest) J:11178 Spies T et al., "Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]" Nature 1991 May 23;351(6324):323-4
(Latest) J:155962 Ruiz S et al., "The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis." PLoS One 2009;4(12):e8229
All references(42)
Other
accession IDs
MGD-MRK-19622, MGI:1919946, MGI:2139071

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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