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Nfatc2 Gene Detail
 Symbol
Name
ID
Nfatc2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
MGI:102463

Nomenclature History
Synonyms NFAT1, NFAT1-D, NFATp
Genetic Map
Chromosome 2
95.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 8)

Sequence Map
Chr2:168301910-168427157 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Nfatc2 ± 2 cM)
TreeFam: TF326480
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016052 VEGA Gene Model | MGI Sequence Detail 125248 C57BL/6J ± Kb
transcript NM_010899 RefSeq | MGI Sequence Detail 6660 C57BL/6
polypeptide Q60591 UniProt | EBI | MGI Sequence Detail 927 Not Applicable
For the selected sequences
All sequences(80)
Alleles
and
phenotypes 		All alleles(10) : Targeted, knock-out(3) Gene trapped(7)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(1) SNPs within 2kb(726 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cytokine production, positive regulation of transcription...
Component cytoplasm, cytosol...
Function DNA binding, protein binding...
External Resources: FuncBase
Expression Literature Summary: (5 records)
Data Summary: Assays (3)    Results (34)    Tissues (34)    Images (4)
Theiler Stages: 17,21,24,28
  Assay Type Assays   Results
      RT-PCR 1   2
      RNA in situ 2   32
cDNA source data(30)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(42) Genomic(6) cDNA(34) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000027544
DoTS DT.101367250, DT.101367251, DT.55149551, DT.87038091, DT.91559754, DT.94248460, DT.97335564, DT.97359441, DT.97369735
Consensus CDS Project CCDS17112.1, CCDS17113.1, CCDS17114.1
UniGene 116802
DFCI TC1585857, TC1625864, TC1630790, TC1637462
NIA Mouse Gene Index U023695
Entrez Gene 18019
VEGA Gene Model OTTMUSG00000016052
International Mouse Knockout Project Status Nfatc2
Protein
domains
InterPro ID Description
IPR002909 Cell surface receptor IPT/TIG
IPR008366 Nuclear factor of activated T cells (NFAT)
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology
IPR013783 Immunoglobulin-like fold
IPR014756 Immunoglobulin E-set
IPR018286 Nuclear factor of activated T cells (NFAT), subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:15443 McCaffrey PG et al., "Isolation of the cyclosporin-sensitive T cell transcription factor NFATp." Science 1993 Oct 29;262(5134):750-4
(Latest) J:155998 Fonseca BP et al., "NFAT1 transcription factor regulates pulmonary allergic inflammation and airway responsiveness." Am J Respir Cell Mol Biol 2009 Jan;40(1):66-75
All references(85)
Other
accession IDs 		MGD-MRK-12824, MGD-MRK-19300, MGI:2139019
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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