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Ap2a2 Gene Detail
 Symbol
Name
ID
Ap2a2
adaptor protein complex AP-2, alpha 2 subunit
MGI:101920

Nomenclature History
Synonyms 2410074K14Rik, Adtab, alpha-adaptin C, alpha-C adaptin, L25
Genetic Map
Chromosome 7
Syntenic
 
Mapping data( 5)
Sequence Map
Chr7:148748136-148818908 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: adaptor protein complex AP-2, alpha subunit
TreeFam: TF300308
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000002957 Ensembl Gene Model | MGI Sequence Detail 70773 C57BL/6J ± Kb
transcript NM_007459 RefSeq | MGI Sequence Detail 4639 C57BL/6
polypeptide P17427 UniProt | EBI | MGI Sequence Detail 938 Not Applicable
For the selected sequences
All sequences(48)
Alleles
and
phenotypes 		All alleles(52) : Gene trapped(52)
Polymorphisms SNPs within 2kb(128 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process endocytosis, intracellular protein transport...
Component clathrin adaptor complex, coated pit...
Function binding, lipid binding...
External Resources: FuncBase
Expression Literature Summary: (2 records)
cDNA source data(12)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(16) Genomic(1) cDNA(15)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000002957
DoTS DT.101207077, DT.101389327, DT.534641, DT.55125322
Consensus CDS Project CCDS40188.1
PDB 1B9K, 1KY6, 1KY7, 1KYD, 1KYF, 1KYU, 1QTP, 1QTS, 1W80, 2JKR, 2JKT, 2VJ0
DFCI TC1571955, TC1641943, TC1720485
NIA Mouse Gene Index U008965
Entrez Gene 11772
International Mouse Knockout Project Status Ap2a2
Protein
domains
InterPro ID Description
IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
IPR009028 Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain
IPR011989 Armadillo-like helical
IPR013038 Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain
IPR013041 Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain
IPR015873 Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain
IPR016024 Armadillo-type fold
IPR017104 Adaptor protein complex AP-2, alpha subunit
Graphical View of Protein Domain Structure
References
(Earliest) J:21441 Robinson MS, "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)." J Cell Biol 1989 Mar;108(3):833-42
(Latest) J:100371 Okada A et al., "Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice." Birth Defects Res A Clin Mol Teratol 2005 Apr;73(4):229-38
All references(16)
Other
accession IDs 		MGD-MRK-18749, MGI:1354776, MGI:1920922, MGI:2142215, MGI:2142324
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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