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Ppard Gene Detail
 Symbol
Name
ID
Ppard
peroxisome proliferator activator receptor delta
MGI:101884

Nomenclature History
Synonyms Nr1c2, NUC1, Peroxisome proliferator-activated receptor beta, PPAR-delta, Pparb, Pparb/d, PPARdelta/beta
Genetic Map
Chromosome 17
13.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 7)

Sequence Map
Chr17:28369711-28438414 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ppard ± 2 cM)
Protein SuperFamily: peroxisome proliferator activated receptor (PPAR)
TreeFam: TF316304
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000023384 VEGA Gene Model | MGI Sequence Detail 68704 C57BL/6J ± Kb
transcript NM_011145 RefSeq | MGI Sequence Detail 3240 C57BL/6
polypeptide P35396 UniProt | EBI | MGI Sequence Detail 440 Not Applicable
For the selected sequences
All sequences(32)
Alleles
and
phenotypes 		All alleles(63) : Targeted, knock-out(4) Targeted, other(6) Gene trapped(53)
Mice homozygous for a number of different targeted mutations show variable prenatal lethality and a range of phenotypes such as placental, brain, skin, hair follicle, adipose and lipid homeostasis abnormalities, growth retardation, reduced fertility, and increased incidence of tumors/induced tumors.
Phenotype Images (2)  
Polymorphisms RFLP(3) SNPs within 2kb(355 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process adipose tissue development, anagen...
Component nucleus
Function DNA binding, enzyme activator activity...
External Resources: FuncBase
Expression Literature Summary: (12 records)
Data Summary: Assays (7)    Results (211)    Tissues (129)    Images (83)
Theiler Stages: 2,3,4,5,15,17,18,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 2   50
      In situ reporter (knock in) 1   112
      RNA in situ 2   33
      Northern blot 2   16
cDNA source data(41)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(46) cDNA(41) Primer pair(3) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000002250
DoTS DT.101248218, DT.101352353, DT.40145035, DT.40156477
Consensus CDS Project CCDS28575.1
UniGene 328914
DFCI TC1582608
Entrez Gene 19015
VEGA Gene Model OTTMUSG00000023384
International Mouse Knockout Project Status Ppard
Protein
domains
InterPro ID Description
IPR000324 Vitamin D receptor
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003074 Peroxisome proliferator-activated receptor
IPR003075 Peroxisome proliferator-activated receptor, beta
IPR008946 Nuclear hormone receptor, ligand-binding
IPR013088 Zinc finger, NHR/GATA-type
Graphical View of Protein Domain Structure
References
(Earliest) J:15412 Chen F et al., "Identification of two mPPAR related receptors and evidence for the existence of five subfamily members." Biochem Biophys Res Commun 1993 Oct 29;196(2):671-7
(Latest) J:156420 Bility MT et al., "Ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase-2 enhances inhibition of skin tumorigenesis." Toxicol Sci 2010 Jan;113(1):27-36
All references(98)
Other
accession IDs 		MGD-MRK-18710
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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