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Tbp Gene Detail
 Symbol
Name
ID
Tbp
TATA box binding protein
MGI:101838


Nomenclature History
Synonyms Gtf2d
Genetic Map
Chromosome 17
8.254 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 14)

Sequence Map
Chr17:15636852-15654391 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat; hamster, golden    (Mammalian Orthology)
Comparative Map (Mouse/Human Tbp ± 2 cM)
Protein SuperFamily: human transcription initiation factor IID
TreeFam: TF300102
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000030550 VEGA Gene Model | MGI Sequence Detail 17540 C57BL/6J ± Kb
transcript NM_013684 RefSeq | MGI Sequence Detail 1842 C57BL/6
polypeptide P29037 UniProt | EBI | MGI Sequence Detail 316 Not Applicable
For the selected sequences
All sequences(27)
Alleles
and
phenotypes
All alleles(7) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(4)
Mice homozygous for one null allele exhibit embryonic lethality caused by hemorrhaging and clotting in the placenta and surviving embryos die prior to weaning. Mice homozygous for another null allele undergo growth arrest after hatching and apoptosis.
Polymorphisms RFLP(2) SNPs within 2kb(71 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(19)
Process regulation of transcription, regulation of transcription, DNA-dependent...
Component cytoplasm, female pronucleus...
Function binding, DNA binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (23 records)
Data Summary: Assays (15)    Results (110)    Tissues (77)    Images (25)
Theiler Stages: 1,2,3,4,5,13,17,20,21,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 10   61
      RNA in situ 5   49
cDNA source data(66)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(87) Genomic(13) cDNA(68) Primer pair(5) Other(1)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000014767
DoTS DT.101377423, DT.101377425, DT.91594787, DT.94142848
UniGene 244820
DFCI TC1577485, TC1608407, TC1637361
Entrez Gene 21374
VEGA Gene Model OTTMUSG00000030550
International Mouse Knockout Project Status Tbp
Protein
domains
InterPro ID Description
IPR000814 TATA-box binding
IPR012294 Transcription factor TFIID, C-terminal/DNA glycosylase, N-terminal
IPR012295 Beta2-adaptin/TATA-box binding, C-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:21431 Tamura T et al., "Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID)." Nucleic Acids Res 1991 Jul 25;19(14):3861-5
(Latest) J:153553 Li C et al., "Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis." Dev Biol 2009 Oct 1;334(1):97-108
All references(54)
Other
accession IDs
MGD-MRK-18659, MGD-MRK-24009

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory