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Fabp5 Gene Detail
 Symbol
Name
ID
Fabp5
fatty acid binding protein 5, epidermal
MGI:101790

Nomenclature History
Synonyms Fabpe E-FABP, Klbp, mal1, Unknown Klbp, keratinocyte lipid binding protein
Genetic Map
Chromosome 3
cytoband A1-A3
 
Mapping data( 3)
Sequence Map
Chr3:10012548-10016607 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: lipid binding protein, FABP type
TreeFam: TF316894
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000029875 VEGA Gene Model | MGI Sequence Detail 4060 C57BL/6J ± Kb
transcript NM_010634 RefSeq | MGI Sequence Detail 932 C57BL/6
polypeptide Q05816 UniProt | EBI | MGI Sequence Detail 135 Not Applicable
For the selected sequences
All sequences(28)
Alleles
and
phenotypes 		All alleles(2) : Targeted, knock-out(1) Targeted, other(1)
Mice homozygous for disruptions in this gene, depending on allele, display impaired skin barrier function or resistance to diet-induced obesity, showing decreased adipose tissue and imporved glucose tolerance and insulin sensitivity.
Polymorphisms SNPs within 2kb(30 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process glucose metabolic process, glucose transport...
Component cytoplasm
Function binding, lipid binding...
External Resources: FuncBase
Expression Literature Summary: (5 records)
Data Summary: Assays (3)    Results (25)    Tissues (21)    Images (15)
Theiler Stages: 3,4,5,20,22,24,26,28
  Assay Type Assays   Results
      RT-PCR 1   7
      RNA in situ 2   18
cDNA source data(162)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(171) Genomic(7) cDNA(163) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000027533
DoTS DT.101277895, DT.537001, DT.97405854
Consensus CDS Project CCDS38388.1
UniGene 741
DFCI TC1572078, TC1606087
NIA Mouse Gene Index U003022, U050629, U164360
Entrez Gene 16592
VEGA Gene Model OTTMUSG00000029875
International Mouse Knockout Project Status Fabp5
Protein
domains
InterPro ID Description
IPR000463 Cytosolic fatty-acid binding
IPR000566 Lipocalin/cytosolic fatty-acid binding protein
IPR011038 Calycin-like
IPR012674 Calycin
Graphical View of Protein Domain Structure
References
(Earliest) J:14048 Krieg P et al., "Tumor-specific overexpression of a novel keratinocyte lipid-binding protein. Identification and characterization of a cloned sequence activated during multistage carcinogenesis in mouse skin." J Biol Chem 1993 Aug 15;268(23):17362-9
(Latest) J:149295 Li B et al., "Regulation of Th17 differentiation by epidermal fatty acid-binding protein." J Immunol 2009 Jun 15;182(12):7625-33
All references(25)
Other
accession IDs 		MGD-MRK-18598
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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