Mouse Tumor Biology Database (MTB)
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Last Database Update
Sunday 27th July 2014
MTB 1.7.0
 
What's New in MTB?  

2013

  • October
    • Researchers can now search MTB for xenograft models and associated data (histology and genomics) contained in the JAX Patient Derived Xenograft (PDX) Resource.

2012

  • December
    • In 2012 MTB presented at the following:
       11th Annual Workshop on the Pathology of Mouse Models for Human Disease,
       Biocuration 2012,
       Mechanisms & Models of Cancer,
       Model Organisms to Human Biology - Cancer Genetics,
       Second Annual Mutant Mouse Necropsy Workshop.
  • September
    • MTB now holds over 50,000 tumor frequency records.
  • July
    • MTB was highlighted in Chapter 3.1 of 'The Laboratory Mouse, 2nd Edition'.
  • June
    • The cancer QTL viewer has been updated. A number of new features have been added including querying and importing features from MGI, importing and exporting features via GFF formatted files.

2011

  • October
    • MTB now holds over 5,000 images, including histopathology, SKY CGH and FISH images.
  • February
    • The cancer QTL viewer has been updated. The improved user interface is the first step in providing more features and enhancements to the viewer.
    • The immunohistochemistry links have been updated and expanded.

2010

  • November
    • Now you can search for cancer-related mouse gene expression data sets that are in NCBI's Gene Expression Omnibus (GEO) archives with the new Gene Expression Data Set Search Form. Users can search by organ, tumor classification, mouse strain or expression assay platform to find relevant gene expression data sets. Search results provide links to external gene expression data as well as MTB tumor frequency records and strain details.
  • October
    • MTB now holds over 40,000 tumor frequency records
  • April
    • You can now search MTB using Human Gene Symbols. Entering all or part of one or more human gene symbols or Entrez Gene Ids into the new Human Gene Search Form returns orthologous mouse symbols and any genetic data attached to these symbols. These data include alleles and transgenes in mouse strains and tumor specific mutations associated with these symbols. Links allow users to view detailed tumor frequency, strain and pathology data. The search page also includes collections of cancer specific human genes reported by various sources which can be used for orthology searches.
  • January
    • The Tumor Frequency Grid, MTB's interactive graphic display of tumor frequencies, displays as a matrix the strain in which tumors were assessed and the organ systems in which tumors were observed. Our newest enhancements to the Grid allow the user to customize the Grid contents on both axes. Thus, the user can select specific strains or strain families and specific organs or organ systems to obtain a Grid showing any desired combination of strains/families and organs/systems. Try these new enhancements here: http://tumor.informatics.jax.org/mtbwi/dynamicGrid.do

2009

  • September
    • MTB was well represented at the 8th Annual Workshop on the Pathology of Mouse Models for Human Disease, September 11-17, 2009 in Bar Harbor, ME. Participation included a platform presentation by Dr. J.P. Sundberg, entitled "Strain specific diseases in mice: Utilizing online resources" and a tutorial / workshop on using MTB and a poster presentation by Dr. D.A. Begley.
  • March
    • MTB announces the addition of a cancer Quantitative Trait Loci (QTL) Viewer. The Viewer allows users to see an overview of all cancer QTLs identified in the mouse or to display QTLs associated with cancer of particular organs. The user can "drill down" to see details of a particular chromosome or QTL, obtain lists of candidate genes in regions of interest, and link out to related data at MGI or the UCSC Genome Browser.

2008

  • December
    • MTB has begun adding cytogenetic assay image data to the image archives. This includes images from spectral karyotyping (SKY), comparative genome hybridization (CGH) and fluorescence in-situ hybridization (FISH) assays of mouse tumors. Users may now refine their genetics searches to only those cytogenetic data associated with an image. Links to cytogenetics image data are also provided in the Genetics section of the Tumor Frequency Details pages (where applicable) (For an example see: http://tumor.informatics.jax.org/mtbwi/assayImageDetails.do?key=7&page=pathology
  • October
    • The Genetics Search Form has been updated and streamlined. Users can search for germline genetic, tumor somatic genetic and, now, cytogenetic data.
  • January
    • MTB now holds over 30,000 tumor frequency records!

2007

  • October
    • MTB announces the incorporation of tumor pathology data and images from the Shock/Ellison Aging Study conducted at the Jackson Aging Center. These images are from young, middle-aged and old mice (male and female) from each of 32 strains. Additional data from this on-going study will be added as it is produced.
  • August
    • MTB is presenting a poster at the Mechanisms & Models of Cancer Meeting, Aug 8 - 12, 2007 at the Salk Institute, La Jolla, California. Stop by and see us!
  • April
    • The National Cancer Institute is spearheading a large initiative to develop a Cancer Biomedical Information Grid (caBIG; http://cabig.nci.nih.gov/). One of the components of caBIG is a database of animal models for cancer research called caMOD (http://cancermodels.nci.nih.gov). Scientific curators from the MTB project are working with the caMOD team on incorportating official standards for gene and mouse strain nomenclature into the caMOD resource. Some of the data related to mouse models of human cancer data represented in MTB have been downloaded from MTB and incorporated into the caMOD database. Additional data (e.g. pathology diagnoses and images, somatic genetic changes in tumors) remain uniquely available at MTB.
  • March
    • MTB is presenting a poster at the Mouse Models at the Frontiers of Cancer Discovery Keystone Symposia, Mar 18 - 23, 2007, Whistler, British Columbia. Stop by and see how we can help your research.
  • February
    • Come and see the MTB poster at Oncogenomics 2007: Dissecting Cancer Through Genome Research, 31 Jan - 3 Feb.

2006

  • October
    • To improve the quality and utility of pathology images available, the Mouse Tumor Database (MTB) announces the incorporation of Zoomify technology (http://www.zoomify.com/) into the web display of pathology images. Zoomify enables the representation of fast and interactive high-quality images on the web using HTML, JPEGs, and Flash. All of these programs are freely available. With Zoomify, users can change the perspective and magnification of an image dynamically. Users whose systems do not support Flash technology will still see pathology images in a static view. An example of a Zoomified image can be viewed at http://tumor.informatics.jax.org/mtbwi/pathologyImageSearchResults.do?referenceKey=93530&maxItems=No+Limit , Image ID: 1393.
  • August
    • The Tumor Frequency Grid has been enhanced and expanded. The strain family and organ entries have been made expandable to show frequency results for sub-strains of a strain family and sub-structures of an organ. Each results cell now has a rollover pop-up window that shows strain of origin, organ of origin, highest reported frequency and number of tumor frequency records. The grid is also now generated dynamically directly from the information in the database rather than being periodically updated.
  • July
    • The Mouse Tumor Biology Database (MTB) announces the release of the Advanced Search Form. This form enables researchers to perform complex queries combining search parameters from multiple basic search forms.
  • June
    • The Mouse Tumor Biology Database (MTB) announces the release of the Mouse Pathology Submission Form (http://tumor.informatics.jax.org/mtbpathwi/). This form enables researchers to submit pathology data directly to MTB for display on the Web.

      The Pathology Submission Form allows researchers to:

      * Create Mouse Records including strain and genetics information.
      * Generate Tumor Diagnosis's specific for a Mouse Record.
      * Include detailed Pathology and Treatment descriptions in each Diagnosis.
      * Attach Images to a Diagnosis to complement the Pathology descriptions.
      * Have editorial access to any of their Data submitted to MTB.

2005

  • May
    • Version 1.0 of the new Mouse Tumor Biology database is now publicly available. With this release MTB has been ported to Sybase as the database platform. This major infrastructure change provides a scalable foundation for future growth of the database and will enable us to develop new dynamic web-based user interfaces and provide programmatic accessible web services.

      Also with version 1.0, MTB's query interfaces and the results pages have been completely redesigned to match the look and feel of the other databases available through the Mouse Genome Informatics (MGI) web site. Look for additional features and new tools to continue to be released in the coming months...

      Currently MTB holds >16,000 tumor instances in >3,500 genetically defined mouse strains and >1,300 pathology images.

2004

2003

  • August 1
    • As a compliment to our growing repository of immunohistochemistry images a list of antibodies is now available in both HTML and Microsoft®Excel format. This list will be updated periodically.

2002

  • July 30
  • May 10
    • The Tumor Search page has been modified to be more user friendly to browsers that don't handle javascript well.
  • March 1
    • MTB has a publication in the March 1, 2002 issue of Cancer Research.

      Näf D, Krupke DM, Sundberg JP, Eppig JT, Bult CJ. 2002. The mouse tumor biology database: a public resource for cancer genetics and pathology of the mouse. Cancer Res 62(5):1235-40. [Abstract]
  • February 8
    • MTB now holds over 10,000 tumor records!
  • January 22
    • We've installed new server software which, we hope, will make the database more stable, faster, and should solve the intermittent network problems that some users may have experienced in the past few months.

2001

  • September 7
    • To enhance our online user support efforts we have added new pop-up window definitions for each field displayed on each of the web pages generated from the database.
    • We have also added a statement about the current status of the database to the "What's New" and "About MTB" pages.
  • February 16
    • Links have been added, where appropriate, from the allele details pop-up window to allele information held in MGD.

2000

  • September 25
    • MTB redesign update: We've spent the past several months putting MTB through a major redesign. The new version, complete with new search capabilities and a more user-friendly interface, is almost ready to load online. Stay tuned!

1999

  • November 16
    • The Pathology section of the database has been greatly enhanced with the addition of a large number of images from the files of the Animal Pathology group at The Jackson Laboratory. These images are accompanied by detailed descriptions provided by The Jackson Laboratory's veterinary pathologist (Dr. John P. Sundberg).
  • January 22
    • Modified displays for more efficient use of space
    • Modified database tables for enhanced speed in returning query results
    • Added access to "tumor notes" information to the "Tumor Types Query Results" screens
  • January 11
    • Replaced 33 black and white tumor pathology images with color versions
    • Expanded table of links to cancer research web sites
    • MTB home page format simplified
    • Enhanced graphics for Tumor Type query summary table

1998

  • October 19
    • MTB prototype database released