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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Jak3
Janus kinase 3
MGI:99928
115 phenotypes from 19 alleles in 22 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Jak3bfy/Jak3bfy
C57BL/6JSfdAnu-Jak3bfy/AnuApb 		abnormal lymphopoiesis J:104190
abnormal T cell subpopulation ratio J:104190
decreased B cell number J:104190
decreased lymphocyte cell number J:104190
decreased T cell number J:104190
decreased thymocyte number J:104190
diarrhea J:104190
small thymus J:104190
Jak3em1(IMPC)Mbp/Jak3+
C57BL/6N-Jak3em1(IMPC)Mbp/MbpMmucd 		abnormal behavior J:211773
abnormal lymph node morphology J:211773
abnormal neural tube morphology J:211773
abnormal placenta morphology J:211773
abnormal spleen morphology J:211773
decreased anxiety-related response J:211773
decreased exploration in new environment J:211773
decreased thigmotaxis J:211773
enlarged lymph nodes J:211773
enlarged spleen J:211773
hyperactivity J:211773
no spontaneous movement J:211773
Jak3em1(IMPC)Mbp/Jak3em1(IMPC)Mbp
C57BL/6N-Jak3em1(IMPC)Mbp/MbpMmucd 		no spontaneous movement J:211773
preweaning lethality, incomplete penetrance J:211773
Jak3m1Btlr/Jak3m1Btlr
C57BL/6J-Jak3m1Btlr 		abnormal T cell subpopulation ratio J:217795
decreased IgG level J:217795
decreased NK cell number J:217795
decreased response to antigen J:217795
decreased single-positive T cell number J:217795
decreased T cell number J:217795
impaired humoral immune response J:217795
increased effector memory CD4-positive, alpha-beta T cell number J:217795
increased effector memory CD8-positive, alpha-beta T cell number J:217795
increased IgE level J:217795
increased neutrophil cell number J:217795
increased single-positive T cell number J:217795
increased susceptibility to Herpesvirales infection J:217795
Jak3m1J/Jak3m1J
B6.Cg-Crb1+ Jak3m1J/Boc 		decreased spleen weight J:265859
decreased thymus weight J:265859
small spleen J:265859
small thymus J:265859
normal vision/eye phenotype J:265859
Jak3M1Pgrs/Jak3+
involves: C57BL/6J * C57BL/10J 		decreased susceptibility to parasitic infection induced morbidity/mortality J:185217
Jak3M1Pgrs/Jak3M1Pgrs
involves: C57BL/6J * C57BL/10J 		absent B cells J:185217
decreased B cell number J:185217
decreased hematopoietic stem cell number J:185217
decreased interferon-gamma secretion J:185217
decreased NK cell number J:185217
decreased susceptibility to parasitic infection induced morbidity/mortality J:185217
enlarged spleen J:185217
increased CD4-positive, alpha-beta T cell number J:185217
increased CD8-positive, alpha-beta T cell number J:185217
increased susceptibility to bacterial infection J:185217
increased susceptibility to bacterial infection induced morbidity/mortality J:185217
small thymus J:185217
Jak3M1Pgrs/Jak3tm1Ljb
involves: 129S4/SvJae * C57BL/6J * C57BL/10J 		decreased susceptibility to parasitic infection induced morbidity/mortality J:185217
Jak3m2Btlr/Jak3m2Btlr
C57BL/6J-Jak3m2Btlr 		increased B cell number J:217796
increased memory B cell number J:217796
Jak3m3Btlr/Jak3m3Btlr
C57BL/6J-Jak3m3Btlr 		abnormal T cell subpopulation ratio J:225935
decreased B cell number J:225935
decreased B-1 B cell number J:225935
decreased IgG level J:225935
decreased immature B cell number J:225935
decreased mature B cell number J:225935
decreased memory B cell number J:225935
decreased NK cell number J:225935
decreased single-positive T cell number J:225935
decreased T cell number J:225935
impaired hematopoiesis J:225935
impaired humoral immune response J:225935
increased effector memory CD8-positive, alpha-beta T cell number J:225935
increased macrophage cell number J:225935
increased myeloid dendritic cell number J:225935
Jak3m4Btlr/Jak3m4Btlr
C57BL/6J-Jak3m4Btlr 		increased CD4-positive, alpha-beta T cell number J:272398
Jak3M5Btlr/Jak3M5Btlr
C57BL/6J-Jak3M5Btlr 		decreased NK T cell number J:272399
Jak3m6Btlr/Jak3m6Btlr
C57BL/6J-Jak3m6Btlr 		decreased CD8-positive, alpha-beta T cell number J:272400
decreased IgG level J:272400
impaired humoral immune response J:272400
increased CD4-positive, alpha-beta T cell number J:272400
Jak3M7Btlr/Jak3M7Btlr
C57BL/6J-Jak3M7Btlr 		abnormal CD4-positive T cell differentiation J:272401
Jak3m8Btlr/Jak3m8Btlr
C57BL/6J-Jak3m8Btlr 		decreased B cell number J:274939
decreased B-1 B cell number J:274939
decreased B-2 B cell number J:274939
decreased CD4-positive, alpha-beta T cell number J:274939
decreased CD8-positive, alpha-beta T cell number J:274939
decreased CD8-positive, naive alpha-beta T cell number J:274939
decreased dendritic cell number J:274939
decreased IgG level J:274939
decreased IgM level J:274939
decreased response to antigen J:274939
decreased T cell number J:274939
impaired humoral immune response J:274939
increased B-1b cell number J:274939
increased effector memory CD4-positive, alpha-beta T cell number J:274939
Jak3tm1Flv/Jak3tm1Flv
involves: 129S1/Sv 		abnormal T cell proliferation J:95794
arrested B cell differentiation J:95794
decreased CD8-positive, alpha-beta T cell number J:95794
enlarged spleen J:95794
increased CD4-positive, alpha-beta T cell number J:95794
small lymph nodes J:95794
thymus hypoplasia J:95794
Jak3tm1Ljb/Jak3+
involves: 129S4/SvJae 		abnormal leukocyte morphology J:56629
decreased lymphocyte cell number J:56629
increased leukocyte cell number J:56629
increased monocyte cell number J:56629
increased neutrophil cell number J:56629
Jak3tm1Ljb/Jak3tm1Ljb
B6;129S4-Jak3tm1Ljb/J 		abnormal dendritic cell differentiation J:123902
abnormal dendritic cell morphology J:123902
abnormal dendritic cell physiology J:123902
abnormal splenic cell ratio J:123902
decreased CD4-positive, alpha-beta T cell number J:123902
decreased CD8-positive, alpha-beta T cell number J:123902
decreased myeloid dendritic cell number J:123902
Jak3tm1Ljb/Jak3tm1Ljb
involves: 129S4/SvJae 		abnormal erythropoiesis J:56629
abnormal leukocyte morphology J:56629
abnormal myelopoiesis J:56629
abnormal spleen morphology J:56629
abnormal spleen white pulp morphology J:56629
abnormal T cell activation J:56629, J:128694
abnormal T cell differentiation J:64861
abnormal T cell physiology J:128694
abnormal thymus cell ratio J:128694
absent B cells J:128694
absent lymph nodes J:128694
chronic inflammation J:56629
decreased lymphocyte cell number J:56629
decreased T cell proliferation J:128694
decreased thymocyte number J:64861
enlarged spleen J:56629
increased leukocyte cell number J:56629
increased monocyte cell number J:56629
increased neutrophil cell number J:56629
thymus hypoplasia J:128694
Jak3tm1Ljb/Jak3tm1Ljb
involves: 129S4/SvJae * C57BL/6 		abnormal B cell morphology J:29722
abnormal immune system physiology J:29722
abnormal leukocyte physiology J:90510
abnormal lymphocyte physiology J:90510
abnormal response to infection J:29722
abnormal splenic cell ratio J:29722
abnormal T cell activation J:29722
arrested B cell differentiation J:29722
decreased IgG level J:29722
decreased immature B cell number J:29722
decreased mature B cell number J:29722
decreased T cell proliferation J:29722
lymph node hypoplasia J:29722
small lymph nodes J:29722
small Peyer's patches J:29722
small thymus J:29722
spleen hypoplasia J:29722
thymus hypoplasia J:29722
Jak3tm1Ljb/Jak3tm1Ljb
Tg(Lck-Jak3)1Ljb/0
involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10 		absent B cells J:128694
absent lymph nodes J:128694
decreased T cell proliferation J:128694
normal immune system phenotype J:128694
Jak3tm1Ljb/Jak3tm1Ljb
Tg(Lck-Jak3)2Ljb/0
involves: 129S4/SvJae * C3H * C57BL/6 		abnormal T cell activation J:56629
enlarged spleen J:56629
normal immune system phenotype J:56629
increased leukocyte cell number J:56629
Jak3tm1Ljb/Jak3tm1Ljb
Tg(Lck-Jak3)2Ljb/0
involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10 		abnormal T cell activation J:128694
abnormal T cell physiology J:128694
absent B cells J:128694
absent lymph nodes J:128694
decreased T cell proliferation J:128694
normal immune system phenotype J:128694
Jak3tm1Tks/Jak3+
involves: 129P2/OlaHsd * C57BL/6 		abnormal leukocyte physiology J:31231
Jak3tm1Tks/Jak3tm1Tks
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell differentiation J:31231
abnormal CD4-positive, alpha beta T cell morphology J:31231
abnormal lymphopoiesis J:31231
abnormal mesenteric lymph node morphology J:31231
abnormal spleen periarteriolar lymphoid sheath morphology J:31231
abnormal spleen white pulp morphology J:31231
abnormal T cell morphology J:31231
abnormal T cell number J:31231
abnormal T cell physiology J:31231
abnormal thymus cortex morphology J:31231
abnormal thymus corticomedullary boundary morphology J:31231
abnormal thymus medulla morphology J:31231
absent Hassall's corpuscle J:31231
absent lymph nodes J:31231
absent NK cells J:31231
decreased B cell number J:31231
decreased pre-B cell number J:31231
decreased thymocyte number J:31231
small spleen J:31231
small thymus medulla J:31231
spleen hypoplasia J:31231
thymus cortex hypoplasia J:31231
thymus hypoplasia J:31231
Jak3wil/Jak3wil
C57BL/6JSfdAnu-Jak3wil/Anu 		arrested B cell differentiation J:104190
decreased CD8-positive, alpha-beta T cell number J:104190
decreased leukocyte cell number J:104190
diarrhea J:104190
large intestinal inflammation J:104190
premature death J:104190
rectal prolapse J:104190
Jak3X887Y/Jak3X887Y
Not Specified 		abnormal hematopoietic system morphology/development J:112658
abnormal immune system organ morphology J:112658
abnormal lymph node morphology J:112658
abnormal lymphocyte morphology J:112658
abnormal spleen morphology J:112658
abnormal thymus morphology J:112658
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory