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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
MGI:99607
65 phenotypes from 9 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Abca1m4620Dajl/Abca1+
involves: C3H/HeSnJ * C57BL/6J * SWR
decreased circulating cholesterol level J:149088
decreased circulating HDL cholesterol level J:149088
Abca1m4620Dajl/Abca1m4620Dajl
involves: C3H/HeSnJ * C57BL/6J * SWR
decreased circulating cholesterol level J:149088
decreased circulating HDL cholesterol level J:149088
increased circulating triglyceride level J:149088
Abca1mpc227H/Abca1mpc227H
involves: BALB/c * C3H/HeH * C57BL/6J
decreased circulating cholesterol level J:234901
Abca1tm1.1Jp/Abca1tm1.1Jp
involves: 129S6/SvEvTac * C57BL/6
abnormal circulating phospholipid level J:98093
decreased circulating cholesterol level J:98093
decreased circulating HDL cholesterol level J:98093
Abca1tm1b(EUCOMM)Hmgu/Abca1+
C57BL/6N-Abca1tm1b(EUCOMM)Hmgu/Bay
abnormal embryo size J:211773
Abca1tm1b(EUCOMM)Hmgu/Abca1tm1b(EUCOMM)Hmgu
C57BL/6N-Abca1tm1b(EUCOMM)Hmgu/Bay
abnormal embryo size J:211773
preweaning lethality, complete penetrance J:211773
Abca1tm1Blt/Abca1tm1Blt
C57BL/6-Abca1tm1Blt
abnormal platelet physiology J:95088
Abca1tm1Jdm/Abca1+
DBA/1LacJ-Abca1tm1Jdm
abnormal circulating phospholipid level J:61679
abnormal lipid homeostasis J:61679
abnormal lung morphology J:61679
decreased circulating cholesterol level J:61679
decreased circulating HDL cholesterol level J:61679
decreased circulating LDL cholesterol level J:61679
Abca1tm1Jdm/Abca1tm1Jdm
DBA/1-Abca1tm1Jdm/J
increased cholesterol efflux J:130777
Abca1tm1Jdm/Abca1tm1Jdm
DBA/1LacJ-Abca1tm1Jdm
abnormal circulating phospholipid level J:61679
abnormal fat-soluble vitamin level J:60210
abnormal lipid homeostasis J:61679
abnormal lung morphology J:61679
abnormal placenta development J:63265
abnormal pulmonary alveolus morphology J:61679
decreased body weight J:60210
decreased circulating cholesterol level J:60210, J:61679
decreased circulating HDL cholesterol level J:60210, J:61679
decreased circulating LDL cholesterol level J:61679
enlarged adrenal glands J:60210
enlarged spleen J:60210
female infertility J:63265
hemorrhage J:63265
impaired macrophage phagocytosis J:63265
increased intestinal cholesterol absorption J:61679
perinatal lethality, incomplete penetrance J:61679
postnatal lethality, incomplete penetrance J:63265
thrombocytopenia J:60210
Abca1tm1Jdm/Abca1tm1Jdm
involves: C57BL/6 * DBA/1LacJ
abnormal thymus morphology J:132254
decreased circulating cholesterol level J:132254
decreased circulating HDL cholesterol level J:132254
normal homeostasis/metabolism phenotype J:132254
impaired macrophage phagocytosis J:132254
perinatal lethality, incomplete penetrance J:132254
Abca1tm1Jdm/Abca1tm1Jdm
involves: DBA/1LacJ
abnormal circulating phytosterol level J:87209
Abca1tm1Jp/Abca1+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J
abnormal cholesterol homeostasis J:98093
abnormal circulating phospholipid level J:98093
decreased circulating cholesterol level J:98093
decreased circulating HDL cholesterol level J:98093
Abca1tm1Jp/Abca1+
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * SJL
decreased circulating cholesterol level J:107802
decreased circulating HDL cholesterol level J:107802
Abca1tm1Jp/Abca1tm1Jp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J
abnormal cholesterol homeostasis J:98093
abnormal circulating phospholipid level J:98093
decreased circulating cholesterol level J:98093
decreased circulating HDL cholesterol level J:98093
decreased circulating LDL cholesterol level J:98093
increased circulating triglyceride level J:98093
Abca1tm1Jp/Abca1tm1Jp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * C57BL/6 * DBA
decreased circulating HDL cholesterol level J:107802
Abca1tm1Jp/Abca1tm1Jp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * DBA * SJL
decreased circulating HDL cholesterol level J:107802
Abca1tm1Jp/Abca1tm1Jp
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * SJL
abnormal enterocyte physiology J:107802
decreased cholesterol efflux J:107802
decreased circulating cholesterol level J:107802
decreased circulating HDL cholesterol level J:107802
decreased circulating LDL cholesterol level J:107802
Abca1tm1Wpfl/Abca1+
involves: 129P2/OlaHsd * C57BL/6J
abnormal placenta labyrinth morphology J:64390
cardiomyopathy J:64390
decreased circulating cholesterol level J:64390
decreased circulating HDL cholesterol level J:64390
heart left ventricle hypertrophy J:64390
heart right ventricle hypertrophy J:64390
lung hemorrhage J:64390
reduced female fertility J:64390
respiratory distress J:64390
Abca1tm1Wpfl/Abca1tm1Wpfl
involves: 129 * C57BL/6
abnormal Sertoli cell morphology J:101966
Abca1tm1Wpfl/Abca1tm1Wpfl
involves: 129P2/OlaHsd * C57BL/6J
abnormal adrenal gland morphology J:64390
abnormal kidney cortex morphology J:64390
abnormal ovary morphology J:64390
abnormal placenta labyrinth morphology J:64390
abnormal Sertoli cell morphology J:64390
abnormal thymus morphology J:64390
abnormal uterus morphology J:64390
cardiomyopathy J:64390
decreased body size J:64390
decreased circulating cholesterol level J:64390, J:68431
decreased circulating estradiol level J:64390
decreased circulating HDL cholesterol level J:64390, J:68431
decreased circulating progesterone level J:64390
decreased intestinal cholesterol absorption J:68431
embryonic growth arrest J:64390
embryonic growth retardation J:64390
glomerulonephritis J:64390
glomerulosclerosis J:64390
heart left ventricle hypertrophy J:64390
heart right ventricle hypertrophy J:64390
hepatic steatosis J:64390
lethality throughout fetal growth and development, incomplete penetrance J:64390
lung hemorrhage J:64390
postnatal lethality, incomplete penetrance J:64390
reduced female fertility J:64390
renal glomerular immunoglobulin deposits J:64390
respiratory distress J:64390
uterus inflammation J:64390
Tg(Prnp-Abca1)EHol/0
involves: C57BL/6 * CBA
abnormal glial cell physiology J:131400
abnormal protein level J:131400
abnormal spermatogenesis J:131400
abnormal testis development J:131400
abnormal testis morphology J:131400
amyloid beta deposits J:131400
decreased testis weight J:131400
normal homeostasis/metabolism phenotype J:131400
male infertility J:131400
multinucleated giant male germ cells J:131400
seminiferous tubule degeneration J:131400
testicular atrophy J:131400

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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory