U2af1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

U2af1
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1
MGI:98884

32 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Mx1-cre)1Cgn/0 U2af1^tm1.1Hev/U2af1⁺ involves: 129S6/SvEvTac * BALB/c * C57BL/6 * C57BL/6J * CBA/J	abnormal bone marrow cell morphology/development	J:267082
	decreased erythrocyte cell number	J:267082
	decreased hematocrit	J:267082
	decreased hematopoietic stem cell number	J:267082
	decreased hemoglobin content	J:267082
	decreased leukocyte cell number	J:267082
	increased mean corpuscular volume	J:267082
	macrocytic anemia	J:267082
	normal mortality/aging	J:267082
	normal neoplasm	J:267082
Tg(Mx1-cre)1Cgn/0 U2af1^tm1Mohi/U2af1^tm1Mohi involves: C57BL/6J * CBA/J	abnormal bone marrow cell morphology/development	J:308564
	abnormal hematopoietic stem cell physiology	J:308564
	anemia	J:308564
	bone marrow failure	J:308564
	decreased bone marrow cell number	J:308564
	decreased common myeloid progenitor cell number	J:308564
	decreased erythrocyte cell number	J:308564
	decreased erythroid progenitor cell number	J:308564
	decreased hematopoietic stem cell number	J:308564
	decreased hemoglobin content	J:308564
	decreased leukocyte cell number	J:308564
	decreased megakaryocyte progenitor cell number	J:308564
	decreased neutrophil cell number	J:308564
	pancytopenia	J:308564
	premature death	J:308564
	thrombocytopenia	J:308564
U2af1^em1(IMPC)J/U2af1⁺ C57BL/6NJ-U2af1^em1(IMPC)J/Mmjax	abnormal auditory brainstem response	J:211773
	abnormal coat/hair pigmentation	J:211773
	abnormal lens morphology	J:211773
	abnormal placement of pupils	J:211773
	abnormal retina blood vessel morphology	J:211773
	cornea opacity	J:211773
	increased grip strength	J:211773
	irregularly shaped pupil	J:211773
	persistence of hyaloid vascular system	J:211773
U2af1^em1(IMPC)J/U2af1^em1(IMPC)J C57BL/6NJ-U2af1^em1(IMPC)J/Mmjax	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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