51 phenotypes from 7 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Myh6-Tpm1*D175N)#Dfw/0 Not Specified	abnormal atrial thrombosis	J:57365
	abnormal heart ventricle pressure	J:57365
	abnormal interventricular septum morphology	J:57365
	abnormal myocardial fiber physiology	J:57365
	abnormal response to exercise	J:57365
	cardiac fibrosis	J:57365
	decreased cardiac muscle contractility	J:57365
	decreased cardiac muscle relaxation	J:57365
	disorganized myocardium	J:57365
	increased myocardial fiber size	J:57365
	myocardium hypertrophy	J:57365
Tg(Myh6-Tpm1*E54K)30Dfw/0 involves: FVB/N	abnormal myocardial fiber morphology	J:137813
	abnormal myocardial fiber physiology	J:137813
	congestive heart failure	J:137813
	decreased cardiac muscle contractility	J:137813
	decreased cardiac muscle relaxation	J:137813
	decreased cardiac output	J:137813
	decreased left ventricle diastolic pressure	J:137813
	decreased left ventricle systolic pressure	J:137813
	decreased physiological sensitivity to xenobiotic	J:137813
	decreased ventricle muscle contractility	J:137813
	dilated cardiomyopathy	J:137813
	dilated heart ventricle	J:137813
	increased heart weight	J:137813
	increased myocardial fiber size	J:137813
	premature death	J:137813
Tg(Myh6-Tpm1*E54K)67Dfw/0 involves: FVB/N	abnormal bronchiole morphology	J:137813
	abnormal myocardial fiber morphology	J:137813
	abnormal myocardial fiber physiology	J:137813
	cardiac interstitial fibrosis	J:137813
	congestive heart failure	J:137813
	decreased cardiac muscle contractility	J:137813
	decreased cardiac muscle relaxation	J:137813
	decreased cardiac output	J:137813
	decreased left ventricle diastolic pressure	J:137813
	decreased left ventricle systolic pressure	J:137813
	decreased physiological sensitivity to xenobiotic	J:137813
	decreased ventricle muscle contractility	J:137813
	dilated cardiomyopathy	J:137813
	dilated heart ventricle	J:137813
	edema	J:137813
	increased body weight	J:137813
	increased heart weight	J:137813
	increased myocardial fiber size	J:137813
	premature death	J:137813
Tg(Myh6-Tpm1*E180G)57Dfw/0 involves: FVB/N	abnormal atrial thrombosis	J:127507
	abnormal calcium ion homeostasis	J:171021
	abnormal cardiac muscle contractility	J:127507, J:172340
	abnormal cardiac muscle relaxation	J:127507, J:172340
	abnormal diastolic filling velocity	J:127507
	abnormal heart left ventricle morphology	J:127507
	abnormal heart septum morphology	J:127507
	abnormal heart ventricle morphology	J:172340
	abnormal myocardial fiber morphology	J:127507
	abnormal myocardial fiber physiology	J:127507
	cardiac fibrosis	J:127507, J:172340
	cardiac hypertrophy	J:127507, J:171021, J:172340
	decreased cardiac muscle contractility	J:171021
	decreased heart rate	J:171021
	heart left ventricle hypertrophy	J:127507
	increased cardiac muscle contractility	J:172340
	increased heart atrium size	J:127507, J:172340
	increased left ventricle diastolic pressure	J:127507, J:172340
	increased lung weight	J:171021
	lethargy	J:127507
	premature death	J:127507
Tpm1em1Clo/Tpm1+ Not Specified	abnormal endocardial heart tube morphology	J:320916
	abnormal heart looping	J:320916
	absent heartbeat	J:320916
	embryonic lethality between implantation and placentation, complete penetrance	J:320916
	hydrops fetalis	J:320916
	pericardial effusion	J:320916
Tpm1tm1Dfw/Tpm1+ involves: 129P2/OlaHsd * Black Swiss	no abnormal phenotype detected	J:45833
Tpm1tm1Dfw/Tpm1tm1Dfw involves: 129P2/OlaHsd * Black Swiss	embryonic lethality, complete penetrance	J:45833
Tpm1tm1Jse/Tpm1tm1Jse involves: 129X1/SvJ * Black Swiss	decreased embryo size	J:44952
	embryonic lethality during organogenesis, complete penetrance	J:44952