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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Tph1
tryptophan hydroxylase 1
MGI:98796
18 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Tph1tm1Bdr/Tph1tm1Bdr
Not Specified
normal behavior/neurological phenotype J:81435
normal skeleton phenotype J:172746
Tph1tm1Kry/Tph1tm1Kry
Tg(Col1a1-cre)1Kry/0
involves: FVB
normal homeostasis/metabolism phenotype J:146078
normal skeleton phenotype J:146078
Tph1tm1Kry/Tph1tm1Kry
Tg(Vil1-cre)20Syr/0
involves: C57BL/6 * DBA/2
decreased serotonin level J:146078
increased bone mass J:146078
increased bone ossification J:146078
increased osteoblast cell number J:146078
increased osteoblast proliferation J:146078
Tph1tm1Mlt/Tph1tm1Mlt
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
abnormal heart left ventricle pressure J:99733
decreased cardiac muscle contractility J:99733
decreased cardiac output J:99733
decreased cardiac stroke volume J:99733
decreased serotonin level J:99733
enlarged heart J:99733
fatigue J:99733
increased heart rate J:99733
pallor J:99733
respiratory distress J:99733
Tph1tm2Lex/Tph1tm2Lex
involves: 129S5/SvEvBrd * C57BL/6J
abnormal serotonin level J:144582
normal behavior/neurological phenotype J:144582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory