Tph1^tm1Mlt
Targeted Allele Detail

Summary

• Symbol: Tph1^tm1Mlt
• Name: tryptophan hydroxylase 1; targeted mutation 1, Jacques Mallet
• MGI ID: MGI:3583821
• Synonyms: TPH1^-
• Gene: Tph1 Location: Chr7:46294065-46321961 bp, - strand Genetic Position: Chr7, 30.43 cM
• Alliance: Tph1^tm1Mlt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99733
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The lacZ gene was inserted by homologous recombination in place of the first coding exon and proximal portion of the following intron, yielding a fusion protein encoded by the first 7 base pairs of endogenous sequence followed by lacZ. The endogenous protein is not detected by immunohistochemistry, but beta galactosidase activity is observed. (J:99733)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph1 Mutation: 39 strains or lines available

References

• Original: J:99733 Cote F, et al., Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13525-30
• All: 23 reference(s)