Tjp1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tjp1
tight junction protein 1
MGI:98759

38 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tjp1^tm1.1Whun/Tjp1^tm1.1Whun involves: C57BL/6 * C57BL/6N	no abnormal phenotype detected	J:226210
Tjp1^tm1.1Whun/Tjp1^tm1.1Whun Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * C57BL/6N * C57BL/6NTac * DBA/2	normal liver/biliary system phenotype	J:306936
Tjp1^tm1.1Whun/Tjp1^tm1.1Whun Tg(Nphs1-cre)33Mska/0 involves: C57BL/6 * C57BL/6N * DBA/2	abnormal glomerular filtration barrier morphology	J:226210
	abnormal kidney morphology	J:226210
	abnormal kidney pelvis morphology	J:226210
	abnormal podocyte foot process morphology	J:226210
	abnormal podocyte slit diaphragm morphology	J:226210
	absent podocyte slit diaphragm	J:226210
	albuminuria	J:226210
	detached podocyte	J:226210
	dilated renal tubule	J:226210
	fused podocyte foot processes	J:226210
	glomerulosclerosis	J:226210
	granular kidney	J:226210
	increased renal glomerulus basement membrane thickness	J:226210
	increased urine protein level	J:226210
	kidney papillary atrophy	J:226210
	pale kidney	J:226210
	podocyte foot process effacement	J:226210
	postnatal growth retardation	J:226210
	renal cast	J:226210
Tjp1^tm1Sats/Tjp1⁺ B6.Cg-Tjp1^tm1Sats	no abnormal phenotype detected	J:222380
Tjp1^tm1Sats/Tjp1^tm1Sats B6.Cg-Tjp1^tm1Sats	abnormal developmental vascular remodeling	J:222380
	abnormal embryonic tissue morphology	J:222380
	abnormal extraembryonic tissue morphology	J:222380
	abnormal notochord morphology	J:222380
	abnormal placental labyrinth vasculature morphology	J:222380
	abnormal visceral yolk sac morphology	J:222380
	abnormal vitelline vascular remodeling	J:222380
	abnormal vitelline vasculature morphology	J:222380
	decreased embryo size	J:222380
	dilated allantois	J:222380
	embryonic growth retardation	J:222380
	embryonic lethality during organogenesis, complete penetrance	J:222380
	failure of chorioallantoic fusion	J:222380
	failure of initiation of embryo turning	J:222380
	increased allantois apoptosis	J:222380
	increased embryonic tissue cell apoptosis	J:222380
	increased neural tube apoptosis	J:222380
Tjp1^tm1Tlch/Tjp1^tm1Tlch Not Specified	no abnormal phenotype detected	J:205841

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23