About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Timp3
tissue inhibitor of metalloproteinase 3
MGI:98754
73 phenotypes from 5 alleles in 9 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Timp3tm1.1(KOMP)Vlcg/Timp3tm1.1(KOMP)Vlcg
C57BL/6N-Timp3tm1.1(KOMP)Vlcg/J
abnormal retina blood vessel morphology J:211773
abnormal retina morphology J:211773
increased mean corpuscular volume J:211773
Timp3tm1Hest/Timp3tm1Hest
either: B6.129S1-Timp3tm1Hest or (involves: 129S1/Sv * CD-1)
abnormal choroid vasculature morphology J:136890
abnormal vascular branching morphogenesis J:136890
Timp3tm1Osya/Timp3tm1Osya
B6.129P2-Timp3tm1Osya
abdominal aorta aneurysm J:193744
abnormal abdominal aorta morphology J:193744
abnormal aorta morphology J:193744
abnormal aorta wall morphology J:193744
abnormal blood vessel physiology J:193744
abnormal kidney morphology J:154849
aortitis J:193744
normal cardiovascular system phenotype J:154849
enlarged kidney J:154849
hydronephrosis J:154849
increased susceptibility to injury J:154849
premature death J:193744
Timp3tm1Osya/Timp3tm1Osya
involves: 129P2/OlaHsd * C57BL/6
abnormal artery morphology J:211441
abnormal blood vessel elastic tissue morphology J:211441
abnormal blood vessel physiology J:211441
abnormal learning/memory/conditioning J:154709
abnormal spatial learning J:154709
abnormal systemic arterial blood pressure J:211441
normal behavior/neurological phenotype J:154709
normal cardiovascular system phenotype J:211441
decreased systemic arterial blood pressure J:211441
decreased vasodilation J:211441
Timp3tm1Osya/Timp3tm1Osya
involves: 129P2/OlaHsd * C57BL/6J
decreased susceptibility to induced hypothermia J:215209
increased body temperature J:215209
increased carbon dioxide production J:215209
increased oxygen consumption J:215209
Timp3tm1Rkho/Timp3tm1Rkho
B6.129-Timp3tm1Rkho
abnormal branching involved in terminal bronchiole morphogenesis J:85546
abnormal cardiac muscle relaxation J:102205
abnormal heart morphology J:102205
abnormal liver lobule morphology J:92948
abnormal pulmonary alveolus wall morphology J:161579
cardiac hypertrophy J:102205
decreased body weight J:102205
decreased left ventricle developed pressure J:102205
decreased left ventricle systolic pressure J:102205
decreased ventricle muscle contractility J:102205
dilated cardiomyopathy J:102205
dilated heart left ventricle J:102205
dilated terminal bronchiole tube J:85546
hepatic necrosis J:92948
impaired liver regeneration J:92948
impaired lung alveolus development J:85546, J:161579
increased hepatocyte apoptosis J:92948
increased susceptibility to induced morbidity/mortality J:92948
increased tumor necrosis factor secretion J:92948
liver inflammation J:92948
normal mortality/aging J:92948, J:102205
overexpanded pulmonary alveolus J:161579
normal respiratory system phenotype J:92948, J:102205
Timp3tm1Rkho/Timp3tm1Rkho
FVB.129-Timp3tm1Rkho
abnormal apoptosis J:71690
abnormal involution of the mammary gland J:71690
abnormal lactation J:71690
normal respiratory system phenotype J:71690
Timp3tm1Rkho/Timp3tm1Rkho
involves: 129 * C57BL/6
abnormal bronchiole morphology J:71609
abnormal heart left ventricle morphology J:112033
abnormal pulmonary alveolus morphology J:71609
abnormal respiratory system physiology J:71609
cardiac fibrosis J:112033
cardiac hypertrophy J:112033
normal cellular phenotype J:71609
congestive heart failure J:112033
decreased cardiac muscle contractility J:112033
dilated cardiomyopathy J:112033
dilated heart left ventricle J:112033
normal endocrine/exocrine gland phenotype J:71609
hunched posture J:71609
increased response of heart to induced stress J:112033
increased susceptibility to induced morbidity/mortality J:112033
lethargy J:71609
overexpanded pulmonary alveolus J:71609
premature death J:71609
pulmonary edema J:112033
normal renal/urinary system phenotype J:71609
respiratory distress J:71609
ruffled hair J:71609
Timp3tm1Web/Timp3+
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
abnormal Bruch membrane morphology J:78059
abnormal retina pigment epithelium morphology J:78059
Timp3tm1Web/Timp3tm1Web
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
abnormal Bruch membrane morphology J:78059
abnormal retina pigment epithelium morphology J:78059

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/16/2024
MGI 6.23
The Jackson Laboratory