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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Thrb
thyroid hormone receptor beta
MGI:98743
47 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Ncoa1tm1Bwo/Ncoa1tm1Bwo
Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1tm1Bwo Thrbtm1Olc
abnormal response/metabolism to endogenous compounds J:126521
increased circulating thyroid-stimulating hormone level J:126521
increased circulating thyroxine level J:126521
increased circulating triiodothyronine level J:126521
Thratm1Jas/Thra+
Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
postnatal growth retardation J:52829
Thratm1Jas/Thratm1Jas
Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
abnormal long bone epiphyseal plate morphology J:52829
abnormal small intestine morphology J:52829
abnormal thyroid follicle morphology J:52829
decreased body weight J:52829
decreased small intestinal villus size J:52829
delayed intestine development J:52829
delayed skeletal maturation J:52829
increased circulating thyroid-stimulating hormone level J:52829
increased circulating thyroxine level J:52829
increased triiodothyronine level J:52829
postnatal growth retardation J:52829
premature death J:52829
thyroid gland hyperplasia J:52829
Thratm1Ven/Thra+
Thrbtm1Df/Thrbtm1Df
B6.129-Thratm1Ven Thrbtm1Df
increased or absent threshold for auditory brainstem response J:73382
Thratm1Ven/Thratm1Ven
Thrbtm1Df/Thrb+
B6.129-Thratm1Ven Thrbtm1Df
normal hearing/vestibular/ear phenotype J:73382
Thratm1Ven/Thratm1Ven
Thrbtm1Df/Thrbtm1Df
B6.129-Thratm1Ven Thrbtm1Df
abnormal auditory brainstem response J:73382
abnormal pituitary hormone level J:117324
abnormal sperm motility J:117324
decreased body weight J:117324
decreased follicle stimulating hormone level J:117324
decreased growth hormone level J:117324
decreased luteinizing hormone level J:117324
decreased prolactin level J:117324
decreased testis weight J:117324
female infertility J:73382
increased thyroid-stimulating hormone level J:117324
Thratm1Ven/Thratm1Ven
Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
increased circulating thyroid-stimulating hormone level J:95391
increased circulating thyroxine level J:95391
increased circulating triiodothyronine level J:95391
normal neoplasm J:95391
small pituitary gland J:95391
Thratm1Ven/Thratm1Ven
Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
abnormal cochlear inner hair cell physiology J:73382
abnormal cochlear outer hair cell physiology J:73382
abnormal organ of Corti morphology J:73382
abnormal pillar cell morphology J:73382
abnormal tectorial membrane morphology J:73382
abnormal tectorial membrane striated-sheet matrix morphology J:73382
decreased body size J:73382
decreased cochlear outer hair cell electromotility J:73382
decreased endocochlear potential J:73382
delayed inner ear development J:73382
enlarged tectorial membrane J:73382
female infertility J:73382
increased susceptibility to xenobiotic induced morbidity/mortality J:73382
Thratm2Ven/Thra+
Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
normal hearing/vestibular/ear phenotype J:118402
postnatal growth retardation J:118402
Thratm2Ven/Thratm2Ven
Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
abnormal thyroid follicle morphology J:118402
abnormal thyroid hormone level J:118402
decreased circulating thyroxine level J:118402
decreased circulating triiodothyronine level J:118402
normal hearing/vestibular/ear phenotype J:118402
postnatal growth retardation J:118402
Thratm3Ven/Thra+
Thrbtm1Df/Thrb+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl
abnormal postnatal growth J:100290
decreased body weight J:100290
Thratm3Ven/Thra+
Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl
decreased body weight J:100290
Thratm3Ven/Thratm3Ven
Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl
preweaning lethality, complete penetrance J:100290
Thrbtm5Few/Thrb+
involves: 129 * C57BL/6
increased circulating thyroxine level J:100929
increased thyroid gland weight J:100929
Thrbtm5Few/Thrbtm5Few
involves: 129 * C57BL/6
increased circulating thyroid-stimulating hormone level J:100929
increased circulating thyroxine level J:100929
increased circulating triiodothyronine level J:100929
increased thyroid gland weight J:100929

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory