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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Thbd
thrombomodulin
MGI:98736
66 phenotypes from 11 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Tg(Tek-cre)1Ywa/0
Thbdtm2Rdr/Thbdtm2Wlr
involves: 129S2/SvPas * C57BL/6 * SJL
abnormal acute phase protein level J:71269
abnormal blood coagulation J:71269
abnormal liver morphology J:71269
abnormal lung morphology J:71269
abnormal placental thrombosis J:71269
abnormal thrombosis J:71269
cardiac fibrosis J:71269
decreased body size J:71269
decreased body weight J:71269
embryonic lethality during organogenesis, incomplete penetrance J:71269
enlarged heart J:71269
gastrointestinal hemorrhage J:71269
hematuria J:71269
hemothorax J:71269
increased circulating interleukin-6 level J:71269
increased heart right ventricle weight J:71269
increased heart weight J:71269
increased megakaryocyte cell number J:71269
increased spleen weight J:71269
intracerebral hemorrhage J:71269
lethality throughout fetal growth and development, incomplete penetrance J:71269
liver hemorrhage J:71269
lung hemorrhage J:71269
pallor J:71269
premature death J:71269
priapism J:71269
pulmonary hypertension J:71269
skin hemorrhage J:71269
slow postnatal weight gain J:71269
thrombocytopenia J:71269
Thbdtm1(THBD)Sltz/Thbd+
either: 129S/SvEv-Thbdtm1(THBD)Sltz or (involves: 129S/SvEv * C57BL/6)
abnormal enzyme/coenzyme activity J:191461
Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz
129S/SvEv-Thbdtm1(THBD)Sltz
abnormal enzyme/coenzyme activity J:191461
preweaning lethality, incomplete penetrance J:191461
Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz
involves: 129S/SvEv * C57BL/6
abnormal enzyme/coenzyme activity J:191461
lethality during fetal growth through weaning, incomplete penetrance J:191461
Thbdtm1.1(KOMP)Vlcg/Thbd+
C57BL/6N-Thbdtm1.1(KOMP)Vlcg/Ucd
pale yolk sac J:211773
Thbdtm1.1(KOMP)Vlcg/Thbdtm1.1(KOMP)Vlcg
C57BL/6N-Thbdtm1.1(KOMP)Vlcg/Ucd
preweaning lethality, complete penetrance J:211773
Thbdtm1.1(THBD)Sltz/Thbd+
either: 129S/SvEv(FVB)-Thbdtm1.1(THBD)Sltz or B6.129S(FVB)-Thbdtm1.1(THBD)Sltz
abnormal enzyme/coenzyme activity J:191461
Thbdtm1.1(THBD)Sltz/Thbdtm1.1(THBD)Sltz
129S/SvEv(FVB)-Thbdtm1.1(THBD)Sltz
abnormal enzyme/coenzyme activity J:191461
preweaning lethality, incomplete penetrance J:191461
Thbdtm1.1(THBD)Sltz/Thbdtm1.1(THBD)Sltz
B6.129S(FVB)-Thbdtm1.1(THBD)Sltz
abnormal enzyme/coenzyme activity J:191461
abnormal response to injury J:191461
lethality during fetal growth through weaning, incomplete penetrance J:191461
Thbdtm1.1Hlwu/Thbdtm1.1Hlwu
Lyz2tm1(cre)Ifo/Lyz2+
B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo
decreased circulating interleukin-6 level J:188879
decreased circulating tumor necrosis factor level J:188879
decreased sensitivity to induced morbidity/mortality J:188879
decreased susceptibility to bacterial infection J:188879
decreased susceptibility to bacterial infection induced morbidity/mortality J:188879
decreased susceptibility to injury J:188879
decreased tumor necrosis factor secretion J:188879
Thbdtm1Emc/Thbdtm1Emc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal circulating protein level J:54997
normal homeostasis/metabolism phenotype J:54997
Thbdtm1Rdr/Thbd+
involves: 129S2/SvPas
no abnormal phenotype detected J:22630
Thbdtm1Rdr/Thbdtm1Rdr
involves: 129S2/SvPas
abnormal embryonic tissue morphology J:22630
abnormal endocardium morphology J:22630
abnormal heart development J:22630
embryonic growth arrest J:22630
embryonic lethality during organogenesis, complete penetrance J:22630
Thbdtm1Wlr/Thbdtm1Wlr
B6.129S2-Thbdtm1Wlr
abnormal blood coagulation J:111502
abnormal heart morphology J:111502
abnormal kidney morphology J:111502
abnormal lung morphology J:111502
abnormal response to injury J:111502
abnormal spleen morphology J:111502
abnormal thrombosis J:111502
decreased circulating tumor necrosis factor level J:111502
increased circulating interleukin-1 beta level J:111502
increased circulating interleukin-6 level J:111502
increased sensitivity to induced morbidity/mortality J:111502
increased susceptibility to endotoxin shock J:111502
Thbdtm1Wlr/Thbdtm2Rdr
involves: 129S2/SvPas * C57BL/6
abnormal blood coagulation J:111502
abnormal heart morphology J:47676, J:111502
abnormal lung morphology J:47676, J:111502
abnormal spleen morphology J:47676, J:111502
abnormal thrombosis J:47676, J:111502
Thbdtm2.1Emc/Thbdtm2.1Emc
involves: 129/Sv * BALB/c * C57BL/6
abnormal leukocyte adhesion J:118000
abnormal leukocyte physiology J:118000
increased circulating interleukin-1 beta level J:118000
increased circulating tumor necrosis factor level J:118000
increased myocardial infarction size J:118000
increased susceptibility to endotoxin shock J:118000
Thbdtm2Emc/Thbdtm2Emc
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
abnormal leukocyte physiology J:118000
increased sensitivity to induced morbidity/mortality J:118000
Thbdtm2Rdr/Thbdtm2Rdr
involves: 129S2/SvPas * C57BL/6
abnormal placenta development J:82224
abnormal trophoblast layer morphology J:82224
decreased trophoblast giant cell number J:82224
embryonic growth arrest J:74855, J:82224
embryonic lethality, complete penetrance J:74855
small ectoplacental cone J:82224

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory