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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Tcf4
transcription factor 4
MGI:98506
34 phenotypes from 7 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Tcf4em1Bdph/?
involves: C57BL/6 * C57BL/6J
abnormal action potential J:254983
abnormal brain morphology J:254983
decreased anxiety-related response J:254983
decreased body weight J:254983
decreased brain weight J:254983
decreased startle reflex J:254983
enhanced long term potentiation J:254983
enhanced NMDA-mediated synaptic currents J:254983
hyperactivity J:254983
impaired spatial learning J:254983
increased prepulse inhibition J:254983
microcephaly J:254983
Tcf4em2Bdph/?
involves: C57BL/6 * C57BL/6J
abnormal brain morphology J:254983
decreased brain weight J:254983
enhanced long term potentiation J:254983
microcephaly J:254983
Tcf4tm1.1Hmb/Tcf4+
involves: 129P2/OlaHsd * C57BL/6J
increased double-negative T cell number J:136143
Tcf4tm1.1Hmb/Tcf4tm1.1Hmb
involves: 129P2/OlaHsd * C57BL/6J
abnormal T cell differentiation J:136143
abnormal T cell physiology J:136143
normal immune system phenotype J:136143
increased double-negative T cell number J:136143
postnatal lethality, complete penetrance J:136143
Tcf4tm1a(EUCOMM)Wtsi/Tcf4+
C57BL/6N-Tcf4tm1a(EUCOMM)Wtsi/Wtsi
decreased caudal vertebrae number J:211773
Tcf4tm1a(EUCOMM)Wtsi/Tcf4tm1a(EUCOMM)Wtsi
C57BL/6N-Tcf4tm1a(EUCOMM)Wtsi/Wtsi
preweaning lethality, incomplete penetrance J:211773
Tcf4tm1Hmb/Tcf4+
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
abnormal habituation to a new environment J:254983
decreased anxiety-related response J:254983
decreased body weight J:254983
decreased prepulse inhibition J:254983
decreased startle reflex J:254983
enhanced long term potentiation J:254983
enhanced NMDA-mediated synaptic currents J:254983
hyperactivity J:254983
impaired spatial learning J:254983
Tcf4tm1Hmb/Tcf4+
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL
abnormal brain morphology J:254983
decreased body weight J:254983
decreased brain weight J:254983
enhanced long term potentiation J:254983
microcephaly J:254983
Tcf4tm1Hmb/Tcf4tm1Zhu
Tg(Kit-cre)143Hmb/?
involves: 129P2/OlaHsd * C57BL/6 * CBA
abnormal B cell differentiation J:65236
decreased double-positive T cell number J:65236
decreased thymocyte number J:65236
spleen hypoplasia J:65236
Tcf4tm1Zhu/Tcf4tm1Zhu
involves: 129P2/OlaHsd
abnormal brain development J:125313
neonatal lethality, complete penetrance J:125313
Tcf4tm1Zhu/Tcf4tm1Zhu
involves: 129P2/OlaHsd * C57BL/6
decreased pro-B cell number J:43324
postnatal lethality, complete penetrance J:43324
Tg(Thy1-Tcf4)1Mjro/0
B6N.FVB-Tg(Thy1-Tcf4)1Mjro
impaired contextual conditioning behavior J:202664
impaired cued conditioning behavior J:202664
Tg(Thy1-Tcf4)1Mjro/0
involves: C57BL/6N * FVB/N
abnormal associative learning J:197081
abnormal prepulse inhibition J:202664
impaired contextual conditioning behavior J:197081, J:202664
impaired cued conditioning behavior J:197081, J:202664
impaired spatial learning J:202664
increased thigmotaxis J:202664
reduced sensorimotor gating J:202664

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory