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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
MGI:98354
21 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Egfrwa2/Egfr+
Fostm2(Fosl1)Wag/Fostm2(Fosl1)Wag
Tg(KRT5-SOS1)892A6Wag/0
involves: 129P2/OlaHsd * C57BL/6 * CBA
decreased tumor growth/size J:175064
increased skin papilloma incidence J:175064
Egfrwa2/Egfr+
Rps6ka3tm1.1Kry/Y
Tg(KRT5-SOS1)892A6Wag/0
involves: 129X1/SvJ * C57BL/6 * CBA
decreased tumor growth/size J:175064
increased skin papilloma incidence J:175064
Egfrwa2/Egfr+
Fostm3.1Wag/Fostm3.1Wag
Tg(KRT5-SOS1)892A6Wag/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
decreased tumor growth/size J:175064
increased skin papilloma incidence J:175064
Egfrwa2/Egfr+
Fostm4.1Wag/Fostm4.1Wag
Tg(KRT5-SOS1)892A6Wag/0
involves: 129P2/OlaHsd * C57BL/6 * CBA
increased skin papilloma incidence J:175064
Egfrwa2/Egfr+
Fostm5.1Wag/Fostm5.1Wag
Tg(KRT5-SOS1)892A6Wag/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
decreased tumor growth/size J:175064
increased skin papilloma incidence J:175064
increased skin tumor incidence J:175064
Egfrwa2/Egfr+
Fostm6.1Wag/Fostm6.1Wag
Tg(KRT5-SOS1)892A6Wag/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
increased skin papilloma incidence J:175064
increased tumor growth/size J:175064
Egfrwa2/Egfr+
Tg(KRT5-SOS1)892A6Wag/0
involves: C57BL/6 * CBA
increased skin papilloma incidence J:175064
increased skin tumor incidence J:175064
Egfrwa2/Egfrwa2
Sos1tm1Dlb/Sos1+
involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
abnormal ciliary body morphology J:38321
abnormal cornea morphology J:38321
abnormal eye anterior chamber morphology J:38321
abnormal lens fiber morphology J:38321
abnormal retina morphology J:38321
anterior iris synechia J:38321
corneal opacity J:38321
corneal vascularization J:38321
eyelids open at birth J:38321
fused cornea and lens J:38321
increased cornea thickness J:38321
microphthalmia J:38321
preweaning lethality, incomplete penetrance J:38321
small lens J:38321
vacuolated lens J:38321
Rag2tm1Fwa/Rag2tm1Fwa
Sos1tm1.1Les/Sos1tm1.1Les
Tg(Lck-cre)1Cwi/0
involves: 129S/SvEv * C57BL/6
abnormal T cell differentiation J:174536
decreased T cell proliferation J:174536

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory