Pde6b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pde6b
phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
MGI:97525

37 phenotypes from 13 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pde6b^atrd1/Pde6b^atrd1 involves: BALB/cAnN * C3H/HeN	abnormal optic disk morphology	J:101336
	blindness	J:101336
	decreased visual acuity	J:101336
	increased susceptibility to age-related retinal degeneration	J:75964, J:101336
	thin retina outer nuclear layer	J:101336
Pde6b^atrd1/Pde6b^rd1 involves: BALB/cAnN * C3H/HeN	abnormal retina morphology	J:101336
	decreased visual acuity	J:101336
	retina degeneration	J:75964, J:101336
Pde6b^atrd1/Pde6b^tm1Eye involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J	abnormal cone electrophysiology	J:200898
	abnormal eye electrophysiology	J:200898
	abnormal ocular fundus morphology	J:200898
	abnormal retina blood vessel morphology	J:200898
	abnormal rod electrophysiology	J:200898
	decreased retina photoreceptor cell number	J:200898
	retina photoreceptor degeneration	J:200898
Pde6b^atrd1/Pde6b^tm1Eye Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J	abnormal ocular fundus morphology	J:200898
	abnormal retina blood vessel morphology	J:200898
	abnormal retina cone cell morphology	J:200898
	decreased retina photoreceptor cell number	J:200898
	retina photoreceptor degeneration	J:200898
	normal vision/eye phenotype	J:200898
Pde6b^atrd2/Pde6b^atrd2 involves: BALB/cAnN * C3H/HeN	abnormal ocular fundus morphology	J:101336
	abnormal optic disk morphology	J:101336
	abnormal retina morphology	J:101336
	blindness	J:101336
	decreased visual acuity	J:101336
	increased susceptibility to age-related retinal degeneration	J:75964, J:101336
	thin retina outer nuclear layer	J:101336
Pde6b^atrd2/Pde6b^rd1 involves: BALB/cAnN * C3H/HeN	abnormal retina morphology	J:101336
	decreased visual acuity	J:101336
	retina degeneration	J:75964, J:101336
	thin retina outer nuclear layer	J:101336
Pde6b^atrd3/Pde6b^atrd3 involves: BALB/cAnN * C3H/HeN	abnormal optic disk morphology	J:101336
	decreased visual acuity	J:101336
	retina degeneration	J:75964, J:101336
	thin retina outer nuclear layer	J:101336
Pde6b^atrd3/Pde6b^rd1 involves: BALB/cAnN * C3H/HeN	retina degeneration	J:75964
Pde6b^rd1-1H/Pde6b^rd1-1H involves: BALB/cAnN * C3H/HeN	retina degeneration	J:75964
Pde6b^rd1-1H/Pde6b^rd1 involves: BALB/cAnN * C3H/HeN	retina degeneration	J:75964
Pde6b^rd1-2H/Pde6b^rd1-2H involves: BALB/cAnN * C3H/HeN	retina degeneration	J:75964
Pde6b^rd1-2H/Pde6b^rd1 involves: BALB/cAnN * C3H/HeN	retina degeneration	J:75964
Pde6b^rd1-2J/Pde6b^rd1-2J C57BL/6J-Pde6b^rd1-2J/J	abnormal eye electrophysiology	J:122722
	abnormal retina vasculature morphology	J:122722
	retina degeneration	J:122722
Pde6b^rd1-3H/Pde6b^rd1-3H involves: BALB/cAnN * C3H/HeN	retina degeneration	J:75964
Pde6b^rd1-3H/Pde6b^rd1 involves: BALB/cAnN * C3H/HeN	retina degeneration	J:75964
Pde6b^rd1-4H/Pde6b^rd1-4H involves: BALB/cAnN * C3H/HeN	retina degeneration	J:75964
Pde6b^rd1-4H/Pde6b^rd1 involves: BALB/cAnN * C3H/HeN	retina degeneration	J:75964
Pde6b^rd1/Pde6b^rd1 B.C3-Pde6b^rd1	retina outer nuclear layer degeneration	J:12044
Pde6b^rd1/Pde6b^rd1 C3H/HeJ	abnormal retina outer nuclear layer morphology	J:66580
	absent photoreceptor outer segment	J:66580
	retina degeneration	J:66580
	normal vision/eye phenotype	J:123259
Pde6b^rd1/Pde6b^rd1 CBA/Ki-Pde6b^rd1	abnormal photoreceptor outer segment morphology	J:5250
Pde6b^rd1/Pde6b^rd1 either: C.Cg-Pde6b^rd1 or C3.Cg-Pde6b^rd1	abnormal Muller cell morphology	J:27850
	abnormal retina morphology	J:27850
	decreased total retina thickness	J:27850
	thin retina outer nuclear layer	J:27850
Pde6b^rd1/Pde6b^rd1 involves: C3H	abnormal ocular fundus morphology	J:101336
	abnormal optic disk morphology	J:101336
	blindness	J:101336
	decreased visual acuity	J:101336
	retina degeneration	J:101336
	thin retina outer nuclear layer	J:101336
Pde6b^rd1/Pde6b^rd1 involves: C57BL/6J	abnormal eye physiology	J:322017
	abnormal retina artery morphology	J:322017
	abnormal retina blood vessel morphology	J:322017
	abnormal retina nerve fiber layer morphology	J:322017
	abnormal retina photoreceptor layer morphology	J:322017
	decreased total retina thickness	J:322017
	retina degeneration	J:322017
	thin retina ganglion layer	J:322017
	thin retina inner plexiform layer	J:322017
	thin retina outer nuclear layer	J:322017
	thin retina outer plexiform layer	J:322017
Pde6b^rd1/Pde6b^rd1 Not Specified	absent retina rod cells	J:24999
Pde6b^rd1/Pde6b^rd1 Not Specified	impaired pupillary reflex	J:81500
Pde6b^rd1/Pde6b^rgsc1754 involves: C3H * C57BL/6JJcl	retina degeneration	J:133634
Pde6b^rd10/Pde6b^rd10 B6.CXB1-Pde6b^rd10/J	abnormal eye electrophysiology	J:117305, J:122722
	abnormal retina rod cell morphology	J:122722
	abnormal retina vasculature morphology	J:122722
	increased susceptibility to age-related retinal degeneration	J:117305, J:122722
	retina outer nuclear layer degeneration	J:122722
	retina rod cell degeneration	J:122722
	normal vision/eye phenotype	J:122722
Pde6b^{tm1b(KOMP)Wtsi}/Pde6b^{tm1b(KOMP)Wtsi} C57BL/6N-Pde6b^{tm1b(KOMP)Wtsi}/Ucd	abnormal heart morphology	J:211773
	enlarged heart	J:211773
	hyperactivity	J:211773

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