Pcx Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pcx
pyruvate carboxylase
MGI:97520

26 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pcx^{tm1b(EUCOMM)Wtsi}/Pcx⁺ C57BL/6N-Pcx^{tm1b(EUCOMM)Wtsi}/H	decreased bone mineral content	J:211773
	decreased lean body mass	J:211773
	decreased respiratory quotient	J:211773
	increased total body fat amount	J:211773
Pcx^{tm1b(EUCOMM)Wtsi}/Pcx⁺ C57BL/6N-Pcx^{tm1b(EUCOMM)Wtsi}/Ieg	increased grip strength	J:211773
Pcx^{tm1b(EUCOMM)Wtsi}/Pcx^{tm1b(EUCOMM)Wtsi} C57BL/6N-Pcx^{tm1b(EUCOMM)Wtsi}/H	preweaning lethality, complete penetrance	J:211773
Pcx^{tm1b(EUCOMM)Wtsi}/Pcx^{tm1b(EUCOMM)Wtsi} C57BL/6N-Pcx^{tm1b(EUCOMM)Wtsi}/Ieg	preweaning lethality, complete penetrance	J:211773
Pcx^{tm1c(EUCOMM)Wtsi}/Pcx^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * C57BL/6N * DBA * SJL	abnormal amino acid metabolism	J:332296
	abnormal fatty acid oxidation	J:332296
	abnormal insulin clearance	J:332296
	abnormal insulin secretion	J:332296
	abnormal liver physiology	J:332296
	abnormal mitochondrial physiology	J:332296
	decreased circulating glucose level	J:332296
	decreased fasting circulating glucose level	J:332296
	normal growth/size/body region phenotype	J:332296
	hepatic steatosis	J:332296
	hypoglycemia	J:332296
	impaired gluconeogenesis	J:332296
	improved glucose tolerance	J:332296
	increased circulating free fatty acids level	J:332296
	increased circulating ketone body level	J:332296
	increased circulating lactate level	J:332296
	increased circulating triglyceride level	J:332296
	increased kidney weight	J:332296
	increased liver triglyceride level	J:332296
	increased susceptibility to weight loss	J:332296

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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