82 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Dmdmdx/Dmd+ Nos1tm1Plh/Nos1tm1Plh involves: 129S4/SvJae * C57BL/10ScSn	abnormal circulating pyruvate kinase level	J:48851
	dystrophic muscle	J:48851
Dmdmdx/Y Nos1tm1Plh/Nos1tm1Plh involves: 129S4/SvJae * C57BL/10ScSn	abnormal circulating pyruvate kinase level	J:48851
	dystrophic muscle	J:48851
Hmox2tm1Poss/Hmox2tm1Poss Nos1tm1Plh/Nos1tm1Plh involves: 129S2/SvPas * 129S4/SvJae	abnormal muscle physiology	J:89581
	abnormal muscle relaxation	J:89581
Leprtm1.1Chua/Leprtm1.2Chua Nos1tm1(cre)Mgmj/Nos1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal behavior/neurological phenotype	J:183754
	decreased circulating thyroxine level	J:183754
	decreased locomotor activity	J:183754
	decreased oxygen consumption	J:183754
	delayed estrous cycle	J:183754
	increased body weight	J:183754
	increased circulating corticosterone level	J:183754
	increased circulating glucose level	J:183754
	increased circulating insulin level	J:183754
	increased circulating leptin level	J:183754
	increased food intake	J:183754
	increased total body fat amount	J:183754
	normal reproductive system phenotype	J:183754
Leprtm1.2Chua/Leprtm1.2Chua Nos1tm1(cre)Mgmj/Nos1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased circulating thyroxine level	J:183754
	decreased locomotor activity	J:183754
	decreased oxygen consumption	J:183754
	increased body weight	J:183754
	increased circulating corticosterone level	J:183754
	increased circulating glucose level	J:183754
	increased circulating insulin level	J:183754
	increased circulating leptin level	J:183754
	increased food intake	J:183754
	increased total body fat amount	J:183754
	reduced female fertility	J:183754
Nos1tm1Plh/Nos1tm1Plh Nos2tm1Lau/Nos2tm1Lau involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J	prenatal lethality, incomplete penetrance	J:83112
Nos1tm1Plh/Nos1tm1Plh Nos2tm1Mrl/Nos2tm1Mrl involves: 129S4/SvJae * 129S7/SvEvBrd	decreased survivor rate	J:100308
	decreased urine osmolality	J:100308
	decreased urine sodium level	J:100308
	increased blood osmolality	J:100308
	increased blood urea nitrogen level	J:100308
	polydipsia	J:100308
	polyuria	J:100308
	premature death	J:100308
	reduced fertility	J:100308
Nos1tm1Plh/Nos1tm1Plh Nos2tm1Mrl/Nos2tm1Mrl Nos3tm1Plh/Nos3tm1Plh involves: 129S4/SvJae * 129S7/SvEvBrd	abnormal bone mineralization	J:150159
	abnormal bone structure	J:150159
	abnormal coronary artery morphology	J:100308
	abnormal glomerular capillary thrombosis	J:100308
	abnormal kidney physiology	J:100308
	abnormal nitric oxide homeostasis	J:100308
	abnormal osteoclast physiology	J:150159
	abnormal renal glomerulus morphology	J:100308
	abnormal skeleton physiology	J:150159
	abnormal trabecular bone morphology	J:150159
	congestive heart failure	J:100308
	decreased heart rate	J:100308
	decreased survivor rate	J:100308
	decreased urine osmolality	J:100308
	decreased urine sodium level	J:100308
	dehydration	J:100308
	enlarged stomach	J:100308
	glomerulosclerosis	J:100308
	hypertension	J:100308
	increased blood osmolality	J:100308
	increased blood urea nitrogen level	J:100308
	increased bone mineral density	J:150159
	increased circulating alkaline phosphatase level	J:150159
	increased circulating creatinine level	J:100308
	increased osteoclast cell number	J:150159
	increased prostaglandin level	J:100308
	increased renal tubule apoptosis	J:100308
	increased systemic arterial blood pressure	J:100308
	increased systemic arterial systolic blood pressure	J:100308
	liver vascular congestion	J:100308
	polydipsia	J:100308
	polyuria	J:100308
	premature death	J:100308
	pulmonary vascular congestion	J:100308
	pyloric sphincter hypertrophy	J:100308
	reduced fertility	J:100308
	renal tubular necrosis	J:100308
	visceral vascular congestion	J:100308
Nos1tm1Plh/Nos1tm1Plh Nos2tm1Mrl/Nos2tm1Mrl Nos3tm1Plh/Nos3tm1Plh involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	abnormal cardiovascular system morphology	J:155090
	abnormal cardiovascular system physiology	J:155090
	abnormal circulating glucose level	J:155090
	abnormal vascular endothelial cell physiology	J:155090
	abnormal vascular wound healing	J:155090
	arteriosclerosis	J:155090
	decreased adiponectin level	J:155090
	hypertension	J:155090
	increased circulating LDL cholesterol level	J:155090
	increased circulating triglyceride level	J:155090
	increased white adipose tissue amount	J:155090
	perivascular fibrosis	J:155090
	premature death	J:155090
	thick ventricular wall	J:155090
Nos1tm1Plh/Nos1tm1Plh Nos3tm1Plh/Nos3tm1Plh B6.129S4-Nos3tm1Plh Nos1tm1Plh	abnormal cardiac muscle relaxation	J:129064
	cardiac interstitial fibrosis	J:129064
	decreased left ventricle diastolic pressure	J:129064
	heart left ventricle hypertrophy	J:129064
	increased cardiac muscle contractility	J:129064
	increased heart rate	J:129064
	increased systemic arterial systolic blood pressure	J:129064
Nos1tm1Plh/Nos1tm1Plh Nos3tm1Plh/Nos3tm1Plh involves: 129S4/SvJae	abnormal sensory neuron innervation pattern	J:61144
	decreased heart rate	J:100308
	decreased survivor rate	J:100308
	decreased urine osmolality	J:100308
	decreased urine sodium level	J:100308
	increased blood osmolality	J:100308
	increased blood urea nitrogen level	J:100308
	increased systemic arterial systolic blood pressure	J:100308
	normal nervous system phenotype	J:37956
	polydipsia	J:100308
	polyuria	J:100308
	premature death	J:100308
	reduced fertility	J:100308
	reduced long-term potentiation	J:37956
Nos1tm1Plh/Nos1tm1Plh Nos3tm1Plh/Nos3tm1Plh involves: 129S4/SvJae * C57BL/6	abnormal cardiac muscle relaxation	J:75645
	decreased cardiac muscle contractility	J:75645
	decreased survivor rate	J:129064
	heart left ventricle hypertrophy	J:75645
	increased cardiac muscle contractility	J:75645
	increased heart rate	J:75645
	increased systemic arterial systolic blood pressure	J:75645
	premature death	J:129064
Nos1tm1Plh/Nos1tm1Plh Nos3tm1Unc/Nos3tm1Unc involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J	prenatal lethality, incomplete penetrance	J:83112
Nos1tm1Plh/Nos1tm1Plh Tg(RHO-VEGFA)V-6Camp/0 involves: 129S4/SvJae * C57BL/6J	abnormal angiogenesis	J:106207
Nos1tm1Plh/Nos1tm1Plh Tg(SOD1)76Dpr/0 involves: 129S4/SvJae * C3H/HeJ * C57BL/6 * C57BL/6J	decreased cerebral infarct size	J:128835
	decreased susceptibility to ischemic brain injury	J:128835