About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nkx2-5
NK2 homeobox 5
MGI:97350
130 phenotypes from 14 alleles in 19 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
Nkx2-5tm1Krc/Nkx2-5tm1Krc
involves: 129 * C57BL/6 		normal cardiovascular system phenotype J:214093
Myl2tm1(cre)Krc/Myl2+
Nkx2-5tm1Krc/Nkx2-5tm1Krc
either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6) 		abnormal atrioventricular bundle morphology J:89404
abnormal impulse conducting system morphology J:89404
abnormal myocardial fiber morphology J:89404
abnormal myocardial trabeculae morphology J:89404
atrioventricular block J:89404
atrioventricular node hypoplasia J:89404
cardiac hypertrophy J:89404
cardiac interstitial fibrosis J:89404
normal cardiovascular system phenotype J:89404
dilated cardiomyopathy J:89404
hydrops fetalis J:89404
perinatal lethality, incomplete penetrance J:89404
Nkx2-5em1Dsr/Nkx2-5em1Dsr
involves: C57BL/6J 		abnormal heart ventricle morphology J:277399
abnormal trabecula carnea morphology J:277399
thin myocardium J:277399
Nkx2-5tm1.1Burg/Nkx2-5+
involves: 129S1/Sv * 129S2/SvPasCrl * 129X1/SvJ 		abnormal heart ventricle morphology J:251389
atrial septal defect J:251389
atrioventricular block J:251389
neonatal lethality, incomplete penetrance J:251389
ostium secundum atrial septal defect J:251389
postnatal lethality, incomplete penetrance J:251389
prolonged PR interval J:251389
ventricular septal defect J:251389
Nkx2-5tm1.1Burg/Nkx2-5tm1.1Burg
involves: 129S1/Sv * 129S2/SvPasCrl * 129X1/SvJ 		abnormal trabecula carnea morphology J:251389
absent atrioventricular cushions J:251389
decreased embryo size J:251389
delayed heart development J:251389
embryonic growth retardation J:251389
embryonic lethality during organogenesis, complete penetrance J:251389
pericardial effusion J:251389
small heart J:251389
thin myocardium J:251389
Nkx2-5tm1.1Gum/Nkx2-5tm1.1Gum
Tg(CAG-cre/Esr1*)5Amc/0
involves: C57BL/6J 		abnormal pyloric sphincter morphology J:228275
abnormal stomach smooth muscle circular layer morphology J:228275
abnormal stomach smooth muscle outer longitudinal layer morphology J:228275
decreased cell proliferation J:228275
increased apoptosis J:228275
Nkx2-5tm1.1Hkas/Nkx2-5+
129S2.Cg-Nkx2-5tm1.1Hkas 		abnormal atrioventricular node conduction J:273097
abnormal atrioventricular node morphology J:273097
abnormal heart morphology J:273096
abnormal heart ventricle morphology J:273096
abnormal impulse conducting system conduction J:273097
abnormal interatrial septum morphology J:273096
abnormal interventricular septum muscular part morphology J:273096
abnormal left posterior bundle morphology J:273097
abnormal tricuspid valve morphology J:273096
atrioventricular block J:273097
atrioventricular septal defect J:273096
cardiomyopathy J:273096
cyanosis J:273096
decreased acetylcholinesterase activity J:273097
double chambered heart right ventricle J:273096
double outlet right ventricle J:273096
Ebstein's malformation of tricuspid valve J:273096
enlarged heart J:273096
muscular ventricular septal defect J:273096
perimembraneous ventricular septal defect J:273096
perinatal lethality, incomplete penetrance J:273096
prolonged PR interval J:273097
prolonged QRS complex duration J:273097
right atrial isomerism J:273096
tricuspid valve atresia J:273096
Nkx2-5tm1.1Hkas/Nkx2-5+
(129S2.Cg-Nkx2-5tm1.1Hkas x C57BL/6)F1 		abnormal heart ventricle morphology J:273096
abnormal tricuspid valve cusp morphology J:273096
normal cardiovascular system phenotype J:273096
muscular ventricular septal defect J:273096
perimembraneous ventricular septal defect J:273096
Nkx2-5tm1.1Hkas/Nkx2-5tm1.1Hkas
129S2.Cg-Nkx2-5tm1.1Hkas 		embryonic growth retardation J:273096
embryonic lethality, complete penetrance J:273096
Nkx2-5tm1.1Krc/Nkx2-5+
129S2.Cg(FVB)-Nkx2-5tm1.1Krc 		abnormal heart ventricle morphology J:273096
abnormal tricuspid valve cusp morphology J:273096
abnormal tricuspid valve morphology J:273096
normal mortality/aging J:273096
muscular ventricular septal defect J:273096
perimembraneous ventricular septal defect J:273096
Nkx2-5tm1.1Pash/Nkx2-5tm1.1Pash
B6.129-Nkx2-5tm1.1Pash 		no abnormal phenotype detected J:101977
Nkx2-5tm1Krc/Nkx2-5tm1Krc
Isl1tm1(cre)Sev/Isl1+
involves: 129 * C57BL/6 		abnormal cardiac outflow tract development J:214093
absent heart right ventricle J:214093
embryonic lethality during organogenesis, complete penetrance J:214093
Nkx2-5tm1Krc/Nkx2-5tm1Krc
Isl1tm1(cre)Tmj/Isl1+
involves: 129X1/SvJ * C57BL/6 		abnormal cardiac outflow tract development J:214093
abnormal conotruncal ridge morphology J:214093
abnormal heart right ventricle morphology J:214093
abnormal myocardial trabeculae morphology J:214093
cyanosis J:214093
decreased heart right ventricle size J:214093
double outlet right ventricle J:214093
heart right ventricle hypoplasia J:214093
perinatal lethality J:214093
persistent truncus arteriosus J:214093
Nkx2-5tm1Krc/Nkx2-5tm1Krc
Tg(Mef2c-cre)#Blk/0
involves: 129 * C57BL/6 		abnormal cardiac outflow tract development J:214093
absent heart right ventricle J:214093
embryonic lethality during organogenesis, complete penetrance J:214093
Nkx2-5tm1Siz/Nkx2-5+
involves: 129S4/SvJaeSor 		abnormal impulse conducting system conduction J:89216
abnormal Purkinje fiber morphology J:89216
atrioventricular block J:89216
decreased ventricle muscle contractility J:174208
prolonged PR interval J:89216
prolonged QRS complex duration J:89216, J:174208
Nkx2-5tm1Siz/Nkx2-5tm1Siz
involves: 129S4/SvJaeSor * C57BL/6J 		abnormal cardiac outflow tract development J:52597
abnormal dorsal aorta morphology J:52597
abnormal embryonic hematopoiesis J:52597
abnormal embryonic tissue morphology J:52597
abnormal extraembryonic tissue morphology J:52597
abnormal fetal atrioventricular canal morphology J:52597
abnormal heart development J:52597
abnormal intersomitic artery morphology J:52597
abnormal visceral yolk sac morphology J:52597
abnormal vitelline vasculature morphology J:52597
absent atrioventricular cushions J:52597
absent myocardial trabeculae J:52597
absent vitelline blood vessels J:52597
anemia J:52597
common ventricle J:52597
decreased cell proliferation J:69976
embryonic growth retardation J:52597
embryonic lethality during organogenesis, complete penetrance J:52597
excessive folding of visceral yolk sac J:52597
pale yolk sac J:52597
pericardial effusion J:52597
pharyngeal arch artery hypoplasia J:52597
pharynx hypoplasia J:69976
Nkx2-5tm1Wehi/Nkx2-5+
involves: 129P2/OlaHsd 		spleen hypoplasia J:184521
Nkx2-5tm1Wehi/Nkx2-5+
involves: 129P2/OlaHsd * C57BL/6J * C57BL/10J 		abnormal aortic valve commissure morphology J:81343
abnormal interatrial septum morphology J:81343
aortic valve stenosis J:81343
atrial septal aneurysm J:81343
atrial septal defect J:81343
bicuspid aortic valve J:81343
patent cardiac foramen ovale J:81343
prolonged PR interval J:81343
thick aortic valve cusps J:81343
Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
involves: 129P2/OlaHsd * C57BL/6J * C57BL/10 		abnormal cardiac outflow tract development J:27443
abnormal fetal atrioventricular canal morphology J:27443
abnormal heart shape J:27443
abnormal heart tube morphology J:27443
abnormal heart ventricle shape J:27443
abnormal myocardium layer morphology J:27443
abnormal myogenesis J:27443
abnormal sinus venosus morphology J:27443
abnormal somite development J:27443
absent atrioventricular cushions J:27443
absent trabeculae carneae J:27443
decreased embryo size J:27443
disorganized myocardium J:27443
edema J:27443
embryonic growth retardation J:27443
embryonic lethality during organogenesis, complete penetrance J:27443
failure of heart looping J:27443
incomplete somite formation J:27443
pericardial edema J:27443
poor circulation J:27443
Nkx2-5tm2(cre)Rph/Nkx2-5tm4Rph
involves: 129S1/Sv 		spleen hypoplasia J:184521
Nkx2-5tm2.1Mwc/Nkx2-5+
B6J.Cg-Nkx2-5tm2.1Mwc/Mwc 		abnormal heart apex morphology J:239808
abnormal heart electrocardiography waveform feature J:239808
abnormal heart left ventricle pressure J:239808
abnormal heart morphology J:239808
abnormal heart right ventricle morphology J:239808
abnormal PR interval J:239808
abnormal QRS complex J:239808
abnormal sinoatrial node conduction J:239808
abnormal ST segment J:239808
atrioventricular node hypoplasia J:239808
decreased cardiac stroke volume J:239808
decreased heart left ventricle weight J:239808
decreased ventricle muscle contractility J:239808
dilated heart right atrium J:239808
dilated heart right ventricle J:239808
irregular heartbeat J:239808
patent cardiac foramen ovale J:239808
prolonged PQ interval J:239808
prolonged QRS complex duration J:239808
shortened ST segment J:239808
sinoatrial block J:239808
Nkx2-5tm2.1Mwc/Nkx2-5tm2.1Mwc
B6J.Cg-Nkx2-5tm2.1Mwc/Mwc 		abnormal heart development J:239808
abnormal heart looping J:239808
embryonic lethality during organogenesis, complete penetrance J:239808
failure of heart looping J:239808
Nkx2-5tm2Siz/Nkx2-5+
involves: 129S4/SvJaeSor 		abnormal atrioventricular node morphology J:89216
abnormal heart development J:89216
abnormal impulse conducting system morphology J:89216
abnormal Purkinje fiber morphology J:89216
heart block J:89216
Nkx2-5tm2Siz/Nkx2-5tm2Siz
involves: 129S4/SvJaeSor 		abnormal cardiac outflow tract development J:89216
abnormal fetal atrioventricular canal morphology J:89216
abnormal heart atrium morphology J:89216
abnormal heart development J:89216
abnormal heart looping J:89216
abnormal heart ventricle shape J:89216
absent atrioventricular node J:89216
embryonic lethality during organogenesis, complete penetrance J:89216
Nkx2-5tm3.1Mwc/Nkx2-5+
B6J.Cg-Nkx2-5tm3.1Mwc/Mwc 		abnormal atrioventricular node morphology J:239808
abnormal heart apex morphology J:239808
abnormal heart electrocardiography waveform feature J:239808
abnormal heart morphology J:239808
abnormal heart right ventricle morphology J:239808
abnormal myocardial fiber physiology J:239808
abnormal sinoatrial node conduction J:239808
atrial septal defect J:239808
decreased ventricle muscle contractility J:239808
dilated heart right atrium J:239808
dilated heart right ventricle J:239808
dilated pulmonary artery J:239808
patent cardiac foramen ovale J:239808
prolonged PQ interval J:239808
prolonged QRS complex duration J:239808
shortened ST segment J:239808
sinoatrial block J:239808
Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
B6J.Cg-Nkx2-5tm3.1Mwc/Mwc 		abnormal heart development J:239808
abnormal heart looping J:239808
embryonic lethality during organogenesis, complete penetrance J:239808
failure of heart looping J:239808
Nkx2-5tm4Rph/Nkx2-5+
either: (involves: 129S1/Sv * 129T2/SvEms) or (involves: 129S1/Sv * C57BL/6J) 		abnormal heart septum morphology J:81343
atrial septal aneurysm J:81343
atrial septal defect J:81343
bicuspid aortic valve J:81343
patent cardiac foramen ovale J:81343
Nkx2-5tm4Rph/Nkx2-5+
either: (involves: 129S1/Sv * C57BL/6 * FVB/N) or (involves: 129S1/Sv * C57BL/6 * QS) 		abnormal interatrial septum morphology J:81343
atrial septal aneurysm J:81343
patent cardiac foramen ovale J:81343
Nkx2-5tm4Rph/Nkx2-5+
involves: 129S1/Sv 		decreased heart left ventricle wall thickness J:98489
decreased ventricle muscle contractility J:98489
dilated heart left atrium J:98489
Nkx2-5tm4Rph/Nkx2-5tm4Rph
either: (involves: 129S1/Sv * 129T2/SvEms) or (involves: 129S1/Sv * C57BL/6J) 		abnormal heart development J:81343
abnormal heart ventricle morphology J:81343
abnormal myocardium layer morphology J:81343
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory