Nkx2-5^tm1.1Pash
Targeted Allele Detail

Summary

• Symbol: Nkx2-5^tm1.1Pash
• Name: NK2 homeobox 5; targeted mutation 1.1, Mohammad Pashmforoush
• MGI ID: MGI:5582820
• Synonyms: Nkx2-5^Flag
• Gene: Nkx2-5 Location: Chr17:27057638-27063962 bp, - strand Genetic Position: Chr17, 13.6 cM
• Alliance: Nkx2-5^tm1.1Pash page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: LSW1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a single loxP site, followed by a frt-flanked neomycin resistance (neo) cassette, upstream of exon 2 of the gene. A 3X Flag sequence and a second loxP site were inserted into exon 2, upstream of the Nkx2-5 stop codon. FLP mediated recombination removed the FRT-flanked neo cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-5 Mutation: 21 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)