Myl2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Myl2
myosin, light polypeptide 2, regulatory, cardiac, slow
MGI:97272

43 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Myl2^{tm1(Hand1)Tana}/Myl2⁺ involves: 129X1/SvJ * C57BL/6J	abnormal heart development	J:91082
	abnormal interventricular groove morphology	J:91082
	common ventricle	J:91082
	embryonic growth retardation	J:91082
	lethality throughout fetal growth and development, complete penetrance	J:91082
	thin myocardium compact layer	J:91082
Myl2^tm1.1Chen/Myl2^tm1.1Chen B6.129-Myl2^tm1.1Chen	normal cardiovascular system phenotype	J:184548
Myl2^tm1.1Chen/Myl2^tm1.1Chen B6.129-Myl2^tm1.1Chen	normal mortality/aging	J:184548
Myl2^{tm1b(EUCOMM)Hmgu}/Myl2⁺ C57BL/6N-Myl2^{tm1b(EUCOMM)Hmgu}/Ieg	absent vibrissae	J:211773
	decreased circulating alkaline phosphatase level	J:211773
	decreased mean corpuscular volume	J:211773
	increased total body fat amount	J:211773
Myl2^{tm1b(EUCOMM)Hmgu}/Myl2^{tm1b(EUCOMM)Hmgu} C57BL/6N-Myl2^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Myl2^tm2.1Chen/Myl2^tm2.1Chen B6.129-Myl2^tm2.1Chen	abnormal myocardial fiber physiology	J:184548
	abnormal Z line morphology	J:184548
	cardiac fibrosis	J:184548
	congestive heart failure	J:184548
	decreased ventricle muscle contractility	J:184548
	dilated cardiomyopathy	J:184548
	dilated heart ventricle	J:184548
	dystrophic cardiac calcinosis	J:184548
	increased heart left ventricle size	J:184548
	increased heart weight	J:184548
	increased myocardial fiber size	J:184548
	increased response of heart to induced stress	J:184548
	premature death	J:184548
	thin interventricular septum	J:184548
Tg(Myh6-Myl2*)21Rbns/0 Not Specified	abnormal cardiac muscle contractility	J:114298
	abnormal cardiac muscle relaxation	J:114298
	abnormal cardiovascular system physiology	J:114298
	abnormal heart septum morphology	J:114298
	abnormal intercalated disk morphology	J:114298
	abnormal myocardial fiber morphology	J:114298
	abnormal myocardial fiber physiology	J:114298
	abnormal sarcomere morphology	J:114298
	cardiac hypertrophy	J:114298
	decreased cardiac muscle contractility	J:110993
	decreased left ventricle developed pressure	J:110993
	decreased systemic arterial systolic blood pressure	J:110993
	dilated heart atrium	J:114298
	dilated heart right ventricle	J:114298
	increased heart atrium size	J:114298
	myocardial fiber degeneration	J:114298
	tricuspid valve regurgitation	J:114298

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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