Tg(Myh6-Myl2*)21Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-Myl2*)21Rbns
• Name: transgene insertion 21, Jeffrey Robbins
• MGI ID: MGI:3688749
• Synonyms: RLC2v(P-), Tg(Myh6-Mylpf*)21Rbns, TG-RLC(P-)
• Transgene: Tg(Myh6-Myl2*)21Rbns Location: unknown
• Alliance: Tg(Myh6-Myl2*)21Rbns page

Abnormal cardiac structure in Tg(Myh6-Myl2*)21Rbns/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Myl2*)21Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myl2 (MGI:97272)

• Mutation details: This transgene consists of the full-length adult mouse (BALB/c) ventricular isoform of Myl2 (regulatory myosin light chain 2) with serines 14, 15, and 19 each mutated and replaced by alanine, under the control of the murine alpha-myosin heavy chain promoter. Replacing the three serines with alanines results in a nonphosphorylatable Myl2. Examination of atrial myofibrillar protein composition shows a progressive replacement of the atrial isoform with the mutated ventricular form as mice age. (J:114298)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:114298 Sanbe A, et al., Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2. J Biol Chem. 1999 Jul 23;274(30):21085-94
• All: 3 reference(s)