Hmga1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hmga1
high mobility group AT-hook 1
MGI:96160

43 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hmga1^tm1Afus/Hmga1⁺ involves: 129S7/SvEvBrd * C57BL/6	cardiac hypertrophy	J:106702
Hmga1^tm1Afus/Hmga1⁺ involves: 129S7/SvEvBrd * C57BL/6	enlarged spleen	J:106702
Hmga1^tm1Afus/Hmga1^tm1Afus involves: 129S7/SvEvBrd * C57BL/6	abnormal myocardium layer morphology	J:106702
	cardiac hypertrophy	J:106702
	decreased body weight	J:106702
	enlarged spleen	J:106702
	heart left ventricle hypertrophy	J:106702
	increased B cell derived lymphoma incidence	J:106702
	increased leukemia incidence	J:106702
	lymphoid hyperplasia	J:106702
	myeloid hyperplasia	J:106702
Hmga1^tm1Brun/Hmga1⁺ Not Specified	decreased circulating insulin level	J:99652
	decreased insulin secretion	J:99652
	impaired glucose tolerance	J:99652
	increased insulin sensitivity	J:99652
	insulin resistance	J:99652
Hmga1^tm1Brun/Hmga1^tm1Brun Not Specified	abnormal pancreatic islet morphology	J:99652
	decreased circulating insulin level	J:99652
	decreased insulin secretion	J:99652
	impaired glucose tolerance	J:99652
	increased insulin sensitivity	J:99652
	insulin resistance	J:99652
	small pancreatic islets	J:99652
Hmga1^tm1Cha/Hmga1⁺ chimera involves: 129S1/Sv * C57BL/6J	abnormal seminiferous tubule epithelium morphology	J:84851
	abnormal seminiferous tubule morphology	J:84851
	abnormal Sertoli cell morphology	J:84851
	abnormal spermatogenesis	J:84851
	azoospermia	J:84851
	decreased male germ cell number	J:84851
	male infertility	J:84851
	small epididymis	J:84851
	small seminiferous tubules	J:84851
	small testis	J:84851
Hmga1^{tm2b(EUCOMM)Hmgu}/Hmga1⁺ C57BL/6N-Hmga1^{tm2b(EUCOMM)Hmgu}/Bay	unresponsive to tactile stimuli	J:211773
Hmga1^{tm2b(EUCOMM)Hmgu}/Hmga1^{tm2b(EUCOMM)Hmgu} C57BL/6N-Hmga1^{tm2b(EUCOMM)Hmgu}/Bay	preweaning lethality, incomplete penetrance	J:211773
	unresponsive to tactile stimuli	J:211773
Tg(H2-K-Hmga1)#Lmsr/0 involves: C57BL/6 * SJL	abnormal endometrium morphology	J:121308
	abnormal intestine morphology	J:184301
	abnormal uterine cervix morphology	J:90252
	decreased locomotor activity	J:90252
	female infertility	J:121308
	increased intestinal mucosa thickness	J:184301
	increased leukemia incidence	J:121308
	increased leukocyte cell number	J:90252
	increased lymphoma incidence	J:90252, J:121308
	increased T cell acute lymphoblastic leukemia incidence	J:90252
	increased uterus leiomyoma incidence	J:121308
	increased uterus tumor incidence	J:121308
	intestine polyps	J:184301
	premature death	J:90252
	rectal prolapse	J:90252
	visceromegaly	J:90252

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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