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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Hbegf
heparin-binding EGF-like growth factor
MGI:96070
49 phenotypes from 7 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Hbegftm1.1Mek/Hbegf+
B6.Cg-Hbegftm1.1Mek
abnormal cardiovascular system physiology J:161948
Hbegftm1.1Mek/Hbegf+
involves: C57BL/6 * C57BL/6J * CBA
no abnormal phenotype detected J:82728
Hbegftm1.1Mek/Hbegftm1.1Mek
B6.Cg-Hbegftm1.1Mek
abnormal atrioventricular valve morphology J:161948
abnormal cardiovascular system physiology J:161948
abnormal heart ventricle outflow tract morphology J:161948
Hbegftm1.1Mek/Hbegftm1.1Mek
involves: C57BL/6 * C57BL/6J * CBA
abnormal aortic valve morphology J:82728
abnormal atrioventricular valve morphology J:82728
abnormal mitral valve morphology J:82728
abnormal pulmonary valve morphology J:82728
abnormal semilunar valve morphology J:82728
abnormal tricuspid valve morphology J:82728
decreased ventricle muscle contractility J:82728
dilated heart left ventricle J:82728
dilated heart right ventricle J:82728
dilated heart ventricle J:82728
enlarged heart J:82728
enlarged myocardial fiber J:82728
postnatal lethality, incomplete penetrance J:82728
premature death J:82728
Hbegftm1Dcl/Hbegftm1Dcl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal atrioventricular valve morphology J:83820
abnormal pulmonary alveolus morphology J:83820
abnormal pulmonary valve morphology J:83820
abnormal semilunar valve morphology J:83820
abnormal type II pneumocyte morphology J:83820
aorta dilation J:83820
aortic valve stenosis J:83820
decreased ventricle muscle contractility J:83820
ectopic cartilage J:83820
enlarged aortic valve J:83820
enlarged heart J:83820
impaired lung alveolus development J:83820
increased heart weight J:83820
postnatal lethality J:83820
premature death J:83820
pulmonary hypoplasia J:83820
pulmonary valve stenosis J:83820
Hbegftm1Hhar/Hbegftm1Hhar
Tg(Six3-cre)69Frty/0
involves: C57BL/6 * CBA * DBA/2
abnormal behavioral response to xenobiotic J:154094
abnormal cerebral cortex pyramidal cell morphology J:154094
abnormal locomotor behavior J:154094
abnormal social investigation J:154094
abnormal spatial reference memory J:154094
decreased prepulse inhibition J:154094
hyperactivity J:154094
Hbegftm1Mek/Hbegftm1Mek
involves: C57BL/6 * C57BL/6J * CBA
no abnormal phenotype detected J:82728
Hbegftm2Mek/Hbegftm2Mek
B6.Cg-Hbegftm2Mek
abnormal atrioventricular valve morphology J:161948
abnormal heart ventricle outflow tract morphology J:161948
Hbegftm2Mek/Hbegftm2Mek
involves: 129/Sv * C57BL/6 * CBA
abnormal atrioventricular valve morphology J:86547
abnormal cardiovascular system morphology J:86547
abnormal cardiovascular system physiology J:86547
abnormal heart size J:86547
abnormal heart valve morphology J:86547
abnormal semilunar valve morphology J:86547
cardiac fibrosis J:86547
decreased cardiac muscle contractility J:86547
dilated cardiomyopathy J:86547
enlarged heart J:86547
premature death J:86547
thin myocardium J:86547
Hbegftm3Mek/Hbegf+
involves: 129/Sv * C57BL/6 * CBA
abnormal myocardial fiber morphology J:86547
cardiac hypertrophy J:86547
decreased body size J:86547
perinatal lethality, incomplete penetrance J:86547
thick epidermis J:86547
Hbegftm4Mek/Hbegf+
B6.Cg-Hbegftm4Mek
abnormal cardiovascular system physiology J:161948
Hbegftm4Mek/Hbegftm4Mek
B6.Cg-Hbegftm4Mek
abnormal atrioventricular valve morphology J:161948
abnormal cardiovascular system physiology J:161948
abnormal heart ventricle outflow tract morphology J:161948
normal cardiovascular system phenotype J:161948
normal respiratory system phenotype J:161948

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory