Hbegftm2Mek
Targeted Allele Detail
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Symbol: |
Hbegftm2Mek |
Name: |
heparin-binding EGF-like growth factor; targeted mutation 2, Eisuke Mekada |
MGI ID: |
MGI:2682958 |
Synonyms: |
HBuc |
Gene: |
Hbegf Location: Chr18:36637980-36648858 bp, - strand Genetic Position: Chr18, 19.46 cM
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Alliance: |
Hbegftm2Mek page
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Enlarged heart with fibrosis and poor left ventricular contraction in Hbegftm2Mek/Hbegftm2Mek mice
Show the 2 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted |
Mutation: |
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Insertion
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Mutation details: Point mutations were introduced in the cDNA sequence which transformed the amino acids residues at positions 148-149 from Leu-Pro to Ser-Thr. The modified cDNA sequence was then fused to the start codon of exon 1 along with IRES, a neomycin resistance gene and a polyadenylation sequence. It is predicted that the resulting product would not be cleavable to release the soluble form of the protein.
(J:86547)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hbegf Mutation: |
25 strains or lines available
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Original: |
J:86547 Yamazaki S, et al., Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities. J Cell Biol. 2003 Nov 10;163(3):469-75 |
All: |
3 reference(s) |
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