Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbegftm2Mek mutation
(0 available);
any
Hbegf mutation
(25 available)
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cardiovascular system
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• atrioventricular valve thickness is increased compared to in wild-type mice
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• outflow tract valve thickness is increased compared to in wild-type mice
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbegftm2Mek mutation
(0 available);
any
Hbegf mutation
(25 available)
|
|
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Enlarged heart with fibrosis and poor left ventricular contraction in Hbegftm2Mek/Hbegftm2Mek mice
mortality/aging
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• about 50% of homozygotes survive beyond 18 weeks
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cardiovascular system
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• wall thickness reduced at 12 weeks
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• massively enlarged heart
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• sporatic fibrosis at 12 weeks
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• poor left ventricular contractions
• reduced cardiac wall movement and ventricular fractional shortening
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muscle
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• wall thickness reduced at 12 weeks
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• poor left ventricular contractions
• reduced cardiac wall movement and ventricular fractional shortening
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growth/size/body
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• massively enlarged heart
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