100 phenotypes from 9 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Grnem1(IMPC)H/Grnem1(IMPC)H C57BL/6NTac-Grnem1(IMPC)H/H	increased mean platelet volume	J:211773
Grntm1.1Aidi/Grntm1.1Aidi involves: C57BL/6 * C57BL/6J	abnormal chemokine secretion	J:156824
	abnormal macrophage physiology	J:156824
	abnormal microglial cell physiology	J:156824
	astrocytosis	J:156824
	increased interleukin-6 secretion	J:156824
	increased interleukin-12 secretion	J:156824
	increased susceptibility to bacterial infection	J:156824
	increased susceptibility to injury	J:156824
	increased tumor necrosis factor secretion	J:156824
	microgliosis	J:156824
Grntm1.1Aidi/Grntm1.1Aidi involves: C57BL/6J	abnormal body weight	J:268827
	abnormal circulating hormone level	J:268827
	abnormal hypothalamus morphology	J:268827
	abnormal hypothalamus secretion	J:268827
	abnormal kidney physiology	J:268827
	abnormal paraventricular hypothalamic nucleus morphology	J:268827
	abnormal renal water homeostasis	J:268827
	abnormal supraoptic nucleus morphology	J:268827
	abnormal zinc homeostasis	J:268827
	astrocytosis	J:268827
	decreased urine creatinine level	J:268827
	decreased urine magnesium level	J:268827
	decreased urine osmolality	J:268827
	decreased urine potassium level	J:268827
	dilated kidney collecting duct	J:268827
	dilated renal tubule	J:268827
	enlarged kidney	J:268827
	normal homeostasis/metabolism phenotype	J:268827
	increased circulating antidiuretic hormone level	J:268827
	increased circulating ghrelin level	J:268827
	increased fluid intake	J:268827
	increased food intake	J:268827
	increased kidney weight	J:268827
	increased liver weight	J:268827
	kidney inflammation	J:268827
	polydipsia	J:268827
	polyuria	J:268827
Grntm1.1Far/Grntm1.1Far B6.129S4(Cg)-Grntm1.1Far	abnormal thalamus neuron morphology	J:259651
	neuronal cytoplasmic inclusions	J:259651
Grntm1.1Far/Grntm1.1Far involves: 129S4/SvJae * C57BL/6J * FVB/N	abnormal cone electrophysiology	J:218705
	abnormal neuron physiology	J:188324, J:218705
	abnormal retina ganglion cell morphology	J:218705
	abnormal retina nerve fiber layer morphology	J:218705
	decreased a-wave amplitude	J:218705
	decreased b-wave amplitude	J:218705
	increased interleukin-1 beta secretion	J:188324
	increased interleukin-6 secretion	J:188324
	increased interleukin-10 secretion	J:188324
	increased susceptibility to dopaminergic neuron neurotoxicity	J:188324
	increased tumor necrosis factor secretion	J:188324
	loss of dopaminergic neurons	J:188324
	microgliosis	J:188324
	neurodegeneration	J:218705
	retina ganglion cell degeneration	J:218705
Grntm1.1Far/Grntm1.1Far involves: 129S4/SvJae * FVB/N	abnormal macrophage physiology	J:170823
Grntm1.1Geno/Grntm1.1Geno involves: 129 * C57BL/6J	abnormal brain morphology	J:188420
	abnormal hepatocyte morphology	J:188420
	abnormal hepatocyte physiology	J:188420
	abnormal liver morphology	J:188420
	abnormal liver parenchyma morphology	J:188420
	abnormal nervous system physiology	J:188420
	abnormal spatial learning	J:188420
	astrocytosis	J:188420
	decreased grooming behavior	J:188420
	increased hepatocyte karyomegaly	J:188420
	microgliosis	J:188420
	premature death	J:188420
Grntm1.1Hiok/Grn+ involves: C57BL/6J	abnormal cell cycle checkpoint function	J:308471
	abnormal cerebral cortex morphology	J:308471
	abnormal endoplasmic reticulum morphology	J:308471
	abnormal frontal lobe morphology	J:308471
	abnormal hippocampus morphology	J:308471
	abnormal long-term spatial reference memory	J:259943
	abnormal midbrain morphology	J:308471
	abnormal primary motor cortex morphology	J:308471
	abnormal retrosplenial region morphology	J:308471
	abnormal thalamus morphology	J:308471
	cellular necrosis	J:308471
	decreased body weight	J:259943
	decreased brain weight	J:259943
	decreased dendritic spine density	J:259943
	impaired contextual conditioning behavior	J:259943
	impaired coordination	J:259943, J:308471
	impaired spatial learning	J:308471
	increased anxiety-related response	J:308471
	increased body weight	J:308471
	nervous system inclusion bodies	J:259943
	neuronal cytoplasmic inclusions	J:259943
	tau protein deposits	J:259943
Grntm1Blrl/Grntm1Blrl involves: C57BL/6J	abnormal dendrite morphology	J:182051
	abnormal excitatory postsynaptic potential	J:182051
	abnormal neurite morphology	J:182051
	abnormal response to novel object	J:182051
	abnormal social investigation	J:182051
	astrocytosis	J:182051
	normal behavior/neurological phenotype	J:182051
	decreased aggression towards male mice	J:182051
	decreased dendritic spine density	J:182051
	impaired coordination	J:182051
	impaired synaptic plasticity	J:182051
	increased thigmotaxis	J:182051
	lipofuscinosis	J:182051
	microgliosis	J:182051
	normal nervous system phenotype	J:182051
	reduced long-term potentiation	J:182051
Grntm1Far/Grntm1Far involves: 129S4/SvJae * C57BL/6J * FVB/N	abnormal neuron physiology	J:188324
Grntm1Far/Grntm1Far Tg(ITGAM-cre)2781Gkl/0 involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N	increased susceptibility to dopaminergic neuron neurotoxicity	J:188324
	loss of dopaminergic neurons	J:188324
	microgliosis	J:188324
Grntm1Mni/Grntm1Mni involves: 129P2/OlaHsd * C57BL/6J	abnormal ejaculation	J:126370
	increased aggression towards male mice	J:126370
	increased anxiety-related response	J:126370
Grntm2.1Far/Grntm2.1Far involves: 129S4/SvJae * C57BL/6	abnormal macrophage physiology	J:259651
	abnormal synapse morphology	J:259651
	abnormal thalamus neuron morphology	J:259651
	decreased survivor rate	J:259651
	increased grooming behavior	J:259651
	lipofuscinosis	J:259651
	microgliosis	J:259651
	neuronal cytoplasmic inclusions	J:259651
	premature death	J:259651
	skin lesions	J:259651