106 phenotypes from 13 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fbn1em1(IMPC)H/Fbn1+ C57BL/6NTac-Fbn1em1(IMPC)H/H	decreased lymphocyte cell number	J:211773
	increased mean platelet volume	J:211773
	increased neutrophil cell number	J:211773
	increased spleen weight	J:211773
Fbn1em1(IMPC)H/Fbn1em1(IMPC)H C57BL/6NTac-Fbn1em1(IMPC)H/H	preweaning lethality, incomplete penetrance	J:211773
Fbn1em1Chop/Fbn1+ C57BL/6-Fbn1em1Chop	abnormal neuron physiology	J:251851
	abnormal postnatal growth/weight/body size	J:251851
	decreased body fat mass	J:251851
	decreased body weight	J:251851
	decreased circulating leptin level	J:251851
	decreased energy expenditure	J:251851
	decreased food intake	J:251851
	decreased lean body mass	J:251851
	decreased susceptibility to diet-induced obesity	J:251851
Fbn1tm1.1Itl/Fbn1tm3Rmz Tg(CMV-cre)1Cgn/0 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ * C57BL/6J	dilated ascending aorta	J:187484
	hemopericardium	J:187484
	hemothorax	J:187484
	postnatal lethality, complete penetrance	J:187484
Fbn1tm1.1Itl/Fbn1tm3Rmz Tg(Prrx1-cre)1Cjt/0 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * SJL/J	abnormal bone marrow cell morphology/development	J:187484
	abnormal bone trabecula morphology	J:187484
	abnormal trabecular bone morphology	J:187484
	decreased bone mass	J:187484
	decreased bone mineral density	J:187484
	decreased bone trabecula number	J:187484
	decreased bone volume	J:187484
	decreased trabecular bone thickness	J:187484
Fbn1tm1.1Itl/Fbn1tm3Rmz Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CD-1	abnormal bone trabecula morphology	J:187484
	abnormal trabecular bone morphology	J:187484
	decreased bone mass	J:187484
	decreased bone mineral density	J:187484
	decreased bone trabecula number	J:187484
	decreased bone volume	J:187484
	decreased trabecular bone thickness	J:187484
Fbn1tm1Hcd/Fbn1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal aorta elastic fiber morphology	J:91349
	abnormal aorta wall morphology	J:91349, J:188799
	abnormal mitral valve cusp morphology	J:94428
	abnormal rib morphology	J:91349
	abnormal skeleton morphology	J:91349
	increased aorta wall thickness	J:94428
	increased heart left atrium size	J:94428
	increased heart left ventricle size	J:94428
	kyphosis	J:91349
	mitral valve prolapse	J:94428
	mitral valve regurgitation	J:94428
	overexpanded pulmonary alveolus	J:91349
Fbn1tm1Hcd/Fbn1tm1Hcd involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal blood vessel morphology	J:91349
	abnormal mitral valve cusp morphology	J:94428
	aortic dissection	J:94428
	postnatal lethality, complete penetrance	J:91349, J:94428
Fbn1tm1Itl/Fbn1tm1Itl involves: 129S1/Sv * 129X1/SvJ	abnormal cardiovascular system morphology	J:187484
	postnatal lethality, complete penetrance	J:187484
Fbn1tm1Lper/Fbn1+ involves: 129/Sv * C57BL/6 * CD-1	abnormal aorta tunica media morphology	J:167276
	abnormal skeleton morphology	J:167276
	emphysema	J:167276
Fbn1tm1Lper/Fbn1+ involves: 129/Sv * CD-1	abnormal aorta elastic fiber morphology	J:167276
	abnormal aorta tunica media morphology	J:167276
	abnormal lung morphology	J:167276
	abnormal respiratory bronchiole morphology	J:167276
	abnormal skeleton morphology	J:167276
	emphysema	J:167276
	hemothorax	J:167276
	kyphosis	J:167276
	lung inflammation	J:167276
	premature death	J:167276
Fbn1tm1Lper/Fbn1tm1Lper involves: 129/Sv * C57BL/6 * CD-1	embryonic lethality during organogenesis, complete penetrance	J:167276
Fbn1tm1Lper/Fbn1tm1Lper involves: 129/Sv * CD-1	embryonic lethality during organogenesis, incomplete penetrance	J:167276
	postnatal lethality, complete penetrance	J:167276
Fbn1tm1Rmz/Fbn1tm1Rmz involves: 129S4/SvJae * C57BL/6J	abnormal aorta morphology	J:43199
	abnormal arterial thrombosis	J:43199
	abnormal lung development	J:91815
	abnormal lung vasculature morphology	J:43199
	abnormal pulmonary alveolus morphology	J:43199
	abnormal pulmonary interalveolar septum morphology	J:91815, J:137934
	abnormal pulmonary neuroendocrine body morphology	J:137934
	aortic dissection	J:43199
	aortic sinus aneurysm	J:43199
	emphysema	J:43199
	hemopericardium	J:43199
	hemothorax	J:43199
	impaired lung alveolus development	J:91815, J:137934
	increased number of pulmonary neuroendocrine bodies	J:137934
	increased solitary pulmonary neuroendocrine cell number	J:137934
	lung hemorrhage	J:43199
	overexpanded pulmonary alveolus	J:91815, J:137934
	postnatal lethality, complete penetrance	J:43199, J:91815
Fbn1tm2.1Hcd/Fbn1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	abnormal cutaneous collagen fibril morphology	J:206074
	abnormal dermal layer morphology	J:206074
	abnormal interleukin secretion	J:206074
	abnormal skin turgor	J:206074
	abnormal T-helper 1 cell morphology	J:206074
	decreased subcutaneous adipose tissue amount	J:206074
	increased anti-nuclear antigen antibody level	J:206074
	increased autoantibody level	J:206074
	increased B cell number	J:206074
	increased interleukin-9 secretion	J:206074
	increased interleukin-13 secretion	J:206074
	increased plasma cell number	J:206074
Fbn1tm2.1Hcd/Fbn1tm2.1Hcd involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	embryonic lethality, complete penetrance	J:206074
Fbn1tm2.1Lysa/Fbn1tm2.1Lysa involves: C57BL/6	normal cardiovascular system phenotype	J:165897
	normal integument phenotype	J:165897
	normal mortality/aging	J:165897
Fbn1tm2Rmz/Fbn1tm2Rmz involves: 129S1/Sv * 129X1/SvJ	abnormal aorta morphology	J:54081
	abnormal aorta tunica adventitia morphology	J:54081
	abnormal aorta tunica intima morphology	J:54081
	abnormal aorta tunica media morphology	J:54081
	abnormal blood vessel morphology	J:54081
	abnormal rib morphology	J:54081
	aortic aneurysm	J:54081
	aortic elastic tissue lesions	J:54081
	aortitis	J:54081
	calcified aorta	J:54081
	decreased bone mineral density	J:187484
	decreased bone trabecula number	J:187484
	decreased bone volume	J:187484
	diaphragmatic hernia	J:54081
	emphysema	J:91815
	enlarged chest	J:54081
	hemopericardium	J:54081
	hemorrhage	J:54081
	hemothorax	J:54081
	impaired lung alveolus development	J:91815
	increased length of long bones	J:54081
	kyphosis	J:54081
	lung inflammation	J:91815
	overexpanded pulmonary alveolus	J:91815
	premature death	J:54081, J:91815
	respiratory distress	J:54081
Fbn1tm3.1Hcd/Fbn1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	abnormal cutaneous collagen fibril morphology	J:206074
	abnormal dermal layer morphology	J:206074
	abnormal interleukin secretion	J:206074
	abnormal skin turgor	J:206074
	abnormal T-helper 1 cell morphology	J:206074
	decreased subcutaneous adipose tissue amount	J:206074
	increased anti-nuclear antigen antibody level	J:206074
	increased autoantibody level	J:206074
	increased B cell number	J:206074
	increased interleukin-9 secretion	J:206074
	increased interleukin-13 secretion	J:206074
	increased plasma cell number	J:206074
Fbn1tm3.1Hcd/Fbn1tm3.1Hcd involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	skin fibrosis	J:206074
Fbn1tm3.2Lysa/Fbn1+ Not Specified	abnormal dermal layer morphology	J:181493
	abnormal skin morphology	J:181493
	brachyphalangia	J:181493
	normal cardiovascular system phenotype	J:181493
	decreased subcutaneous adipose tissue amount	J:181493
	short metacarpal bones	J:181493
	thick dermal layer	J:181493
	thick skin	J:181493
Fbn1tm3.2Lysa/Fbn1tm3.2Lysa Not Specified	abnormal dermal layer morphology	J:181493
	abnormal skin morphology	J:181493
	brachyphalangia	J:181493
	normal cardiovascular system phenotype	J:181493
	decreased length of long bones	J:181493
	decreased subcutaneous adipose tissue amount	J:181493
	short metacarpal bones	J:181493
	short radius	J:181493
	short tibia	J:181493
	short ulna	J:181493
	thick dermal layer	J:181493
	thick skin	J:181493
Fbn1tm3Rmz/Fbn1tm3Rmz involves: C57BL/6	abnormal bone remodeling	J:166786
Fbn1tm3Rmz/Fbn1tm3Rmz Not Specified	abnormal aorta elastic fiber morphology	J:110586
	abnormal aorta elastic tissue morphology	J:110586
	abnormal diaphragm morphology	J:110586
	abnormal intercostal muscle morphology	J:110586
	abnormal rib morphology	J:110586
	abnormal skin tensile strength	J:110586
	ascending aorta aneurysm	J:110586
	decreased respiration	J:110586
	diaphragmatic hernia	J:110586
	hemopericardium	J:110586
	hemothorax	J:110586
	long ribs	J:110586
	overexpanded pulmonary alveolus	J:110586
	postnatal lethality, complete penetrance	J:110586, J:187484