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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
MGI:88594
37 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Cyp27a1tm1.1(KOMP)Vlcg/Cyp27a1tm1.1(KOMP)Vlcg
C57BL/6N-Cyp27a1tm1.1(KOMP)Vlcg/Ucd
abnormal heart morphology J:211773
decreased circulating cholesterol level J:211773
decreased circulating HDL cholesterol level J:211773
decreased circulating triglyceride level J:211773
decreased heart rate J:211773
decreased mean platelet volume J:211773
enlarged heart J:211773
improved glucose tolerance J:211773
increased circulating alkaline phosphatase level J:211773
increased lean body mass J:211773
increased liver weight J:211773
prolonged RR interval J:211773
shortened QRS complex duration J:211773
Cyp27a1tm1Elt/Cyp27a1tm1Elt
B6.129-Cyp27a1tm1Elt/J
abnormal vitamin D level J:223194
decreased circulating phosphate level J:223194
enlarged liver J:223194
Cyp27a1tm1Elt/Cyp27a1tm1Elt
involves: 129/Sv * C57BL/6J
abnormal bile composition J:48127, J:115373
abnormal bile salt homeostasis J:115373
abnormal circulating cholesterol level J:48127
abnormal feces composition J:115373
abnormal vitamin D level J:48127
decreased bile salt level J:115373
decreased brain weight J:115373
decreased cholesterol level J:115373
decreased intestinal cholesterol absorption J:115373
decreased kidney weight J:115373
enlarged adrenal glands J:115373
enlarged adrenocortical cells J:115373
enlarged liver J:115373
normal homeostasis/metabolism phenotype J:115373
increased adrenal gland weight J:115373
increased cholesterol level J:48127, J:115373
increased circulating cholesterol level J:115373
increased circulating triglyceride level J:115373
increased circulating VLDL cholesterol level J:115373
increased circulating VLDL triglyceride level J:115373
increased fatty acids level J:115373
increased liver triglyceride level J:115373
increased liver weight J:115373
increased sterol level J:115373

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory