Chd1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chd1
chromodomain helicase DNA binding protein 1
MGI:88393

24 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chd1^tm1.1Alsr/Chd1^tm1.1Alsr involves: BALB/cJ * C57BL/6 * C57BL/6NCrl	no abnormal phenotype detected	J:231724
Chd1^{tm1b(KOMP)Rsan}/Chd1^{tm1b(KOMP)Rsan} involves: 129P2/OlaHsd * C57BL/6J	abnormal cell cycle	J:217689
	abnormal developmental patterning	J:217689
	abnormal embryo development	J:217689
	abnormal mesoderm development	J:217689
	abnormal rostral-caudal axis patterning	J:217689
	absent anterior visceral endoderm	J:217689
	absent extraembryonic ectoderm	J:217689
	decreased embryo size	J:217689
	embryonic lethality, complete penetrance	J:217689
	failure to gastrulate	J:217689
	increased embryonic epiblast cell apoptosis	J:217689
	small embryonic epiblast	J:217689
Chd1^{tm1b(KOMP)Wtsi}/Chd1⁺ C57BL/6N-Chd1^{tm1b(KOMP)Wtsi}/Tcp	abnormal embryo size	J:211773
	abnormal eye morphology	J:211773
	abnormal maxilla morphology	J:211773
	abnormal tooth morphology	J:211773
	anophthalmia	J:211773
	decreased mean corpuscular hemoglobin concentration	J:211773
	decreased red blood cell distribution width	J:211773
	increased grip strength	J:211773
Chd1^{tm1b(KOMP)Wtsi}/Chd1^{tm1b(KOMP)Wtsi} C57BL/6N-Chd1^{tm1b(KOMP)Wtsi}/Tcp	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Chd1^{tm1c(KOMP)Rsan}/Chd1^{tm1c(KOMP)Rsan} Edil3^{Tg(Sox2-cre)1Amc}/? involves: 129P2/OlaHsd * C57BL/6J * CBA	embryonic lethality, complete penetrance	J:217689

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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