Cers6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cers6
ceramide synthase 6
MGI:2442564

24 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cers6^tm1.1Arte/Cers6^tm1.1Arte involves: BALB/cJ * C57BL/6N	abnormal cellular respiration	J:215519
	abnormal ceramide level	J:215519
	decreased brown fat cell lipid droplet size	J:215519
	decreased circulating insulin level	J:215519
	decreased circulating leptin level	J:215519
	decreased fat cell size	J:215519
	decreased inflammatory response	J:215519
	decreased susceptibility to diet-induced obesity	J:215519
	decreased total body fat amount	J:215519
	enhanced lipolysis	J:215519
	improved glucose tolerance	J:215519
	increased energy expenditure	J:215519
	increased fatty acid oxidation	J:215519
Cers6^tm1.1Kwi/Cers6^tm1.1Kwi involves: 129P2/OlaHsd * C57BL/6	abnormal habituation to a new environment	J:201327
	abnormal hippocampus morphology	J:201327
	abnormal lipid homeostasis	J:201327
	normal behavior/neurological phenotype	J:201327
	impaired coordination	J:201327
	increased locomotor activity	J:201327
	increased vertical activity	J:201327
	limb grasping	J:201327
	microgliosis	J:201327
	nervous	J:201327
Cers6^tm1Arte/Cers6^tm1Arte Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * C57BL/6N	normal homeostasis/metabolism phenotype	J:215519
Cers6^tm1Arte/Cers6^tm1Arte Tg(Alb1-cre)7Gsc/0 involves: C57BL/6N * FVB/N	abnormal ceramide level	J:215519
	decreased susceptibility to diet-induced obesity	J:215519
	improved glucose tolerance	J:215519

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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