Cers6^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Cers6^tm1Arte
• Name: ceramide synthase 6; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:5607416
• Synonyms: CerS6^fl, CerS6^loxP
• Gene: Cers6 Location: Chr2:68691785-68944626 bp, + strand Genetic Position: Chr2, 39.53 cM
• Alliance: Cers6^tm1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215519
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 4 was flanked by loxP sites. (J:215519)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cers6 Mutation: 40 strains or lines available

References

• Original: J:215519 Turpin SM, et al., Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab. 2014 Oct 7;20(4):678-86
• All: 2 reference(s)