Tbc1d4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tbc1d4
TBC1 domain family, member 4
MGI:2429660

32 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tbc1d4^tm1.1Arte/Tbc1d4^tm1.1Arte involves: C57BL/6	decreased body size	J:169477
	decreased muscle cell glucose uptake	J:169477
	decreased spleen weight	J:169477
	impaired glucose tolerance	J:169477
	increased adipocyte glucose uptake	J:169477
	increased heart weight	J:169477
	increased muscle cell glucose uptake	J:169477
	increased testis weight	J:169477
	insulin resistance	J:169477
Tbc1d4^tm1.1Arte/Tbc1d4^tm1.1Arte Not Specified	normal homeostasis/metabolism phenotype	J:186867
Tbc1d4^tm1.1Arte/Tbc1d4^tm1.1Arte Not Specified	normal muscle phenotype	J:186867
Tbc1d4^tm1.2Arte/Tbc1d4^tm1.2Arte involves: C57BL/6 * CBA	abnormal gluconeogenesis	J:194026
	abnormal glucose homeostasis	J:194026
	decreased adipocyte glucose uptake	J:194026
	decreased adiponectin level	J:194026
	decreased basal metabolism	J:194026
	decreased circulating glucose level	J:194026
	decreased circulating insulin level	J:194026
	decreased energy expenditure	J:194026
	decreased muscle cell glucose uptake	J:194026
	decreased oxygen consumption	J:194026
	impaired glucose tolerance	J:194026
	increased adipocyte glucose uptake	J:194026
	increased circulating free fatty acids level	J:194026
	insulin resistance	J:194026
Tbc1d4^{tm1b(EUCOMM)Hmgu}/Tbc1d4^{tm1b(EUCOMM)Hmgu} C57BL/6N-Tbc1d4^{tm1b(EUCOMM)Hmgu}/J	abnormal lens morphology	J:211773
	decreased circulating chloride level	J:211773
	decreased leukocyte cell number	J:211773
	increased circulating sodium level	J:211773
	increased hematocrit	J:211773
	increased mean corpuscular volume	J:211773
Tbc1d4^tm1Lex/Tbc1d4^tm1Lex involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N	abnormal glycogen homeostasis	J:191749
	decreased adipocyte glucose uptake	J:191749
	decreased circulating glucose level	J:191749
	decreased circulating insulin level	J:191749
	decreased muscle cell glucose uptake	J:191749
	impaired glucose tolerance	J:191749
	increased adipocyte glucose uptake	J:191749
	increased epididymal fat pad weight	J:191749
	increased parametrial fat pad weight	J:191749
	increased white fat cell size	J:191749
	insulin resistance	J:191749
	lethality, incomplete penetrance	J:191749

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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