Tbc1d4^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Tbc1d4^tm1.1Arte
• Name: TBC1 domain family, member 4; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:4941737
• Synonyms: AS160^T649A
• Gene: Tbc1d4 Location: Chr14:101679796-101846627 bp, - strand Genetic Position: Chr14, 50.9 cM
• Alliance: Tbc1d4^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169477
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 10 was replaced with an FRT-flanked neo cassette with a 5' loxP site and a modified exon 10 in which nucleotide substitutions result in the amino acid substitution of alanine for threonine at position 649 (T649A) followed by a loxP site. Flp-mediate recombination removed the neo cassette. (J:169477)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbc1d4 Mutation: 50 strains or lines available

References

• Original: J:169477 Chen S, et al., Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking. Cell Metab. 2011 Jan 5;13(1):68-79
• All: 4 reference(s)