Nae1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nae1
NEDD8 activating enzyme E1 subunit 1
MGI:2384561

34 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nae1^{tm1b(EUCOMM)Wtsi}/Nae1⁺ C57BL/6N-Nae1^{tm1b(EUCOMM)Wtsi}/Ics	decreased erythrocyte cell number	J:211773
	decreased exploration in new environment	J:211773
	increased circulating phosphate level	J:211773
	increased fasting circulating glucose level	J:211773
	increased mean corpuscular volume	J:211773
Nae1^{tm1b(EUCOMM)Wtsi}/Nae1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Nae1^{tm1b(EUCOMM)Wtsi}/Ics	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Nae1^{tm1c(EUCOMM)Wtsi}/Nae1^{tm1c(EUCOMM)Wtsi} Tg(Camk2a-cre/ERT2)2Gsc/0 Tg(Thy1-EGFP)MJrs/0 involves: C57BL/6J * C57BL/6N * CBA * FVB/N * SJL	abnormal CNS synaptic transmission	J:262411
	abnormal dendritic spine morphology	J:262411
	abnormal spatial working memory	J:262411
	normal behavior/neurological phenotype	J:262411
	decreased dendritic spine density	J:262411
	impaired long-term object recognition memory	J:262411
	impaired short-term object recognition memory	J:262411
Nae1^{tm1c(EUCOMM)Wtsi}/Nae1^{tm1c(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds/0 involves: C57BL/6J * C57BL/6N * FVB/N * SJL	abnormal heart development	J:261328
	abnormal myocardial trabeculae morphology	J:261328
	abnormal myocardium layer morphology	J:261328
	cardiac hypertrophy	J:261328
	cyanosis	J:261328
	decreased fetal cardiomyocyte proliferation	J:261328
	decreased heart left ventricle wall thickness	J:261328
	decreased heart rate	J:261328
	decreased ventricle muscle contractility	J:261328
	dilated heart left ventricle	J:261328
	dilated heart right ventricle	J:261328
	enlarged heart	J:261328
	extremity edema	J:261328
	increased heart weight	J:261328
	increased myocardial fiber size	J:261328
	myocardium hypoplasia	J:261328
	postnatal lethality, complete penetrance	J:261328
	thin left ventricle myocardium compact layer	J:261328
	thin ventricle myocardium compact layer	J:261328

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23