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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lrrk1
leucine-rich repeat kinase 1
MGI:2142227
62 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Lrrk1m1Btlr/Lrrk1m1Btlr
C57BL/6J-Lrrk1m1Btlr/Btlr
increased bone mineral density J:309727
short femur J:309727
short tibia J:309727
small pubis J:309727
Lrrk1M2Btlr/Lrrk1+
C57BL/6J-Lrrk1m2Btlr/Btlr
short femur J:309727
short tibia J:309727
normal skeleton phenotype J:309727
Lrrk1tm1.1Mjff/Lrrk1tm1.1Mjff
C57BL/6-Lrrk1tm1.1Mjff
preweaning lethality, incomplete penetrance J:184821
Lrrk1tm1.1Smo/Lrrk1tm1.1Smo
involves: 129S/Sv
abnormal bone marrow cavity morphology J:208677
abnormal bone mineralization J:208677
abnormal facial morphology J:208677
abnormal long bone metaphysis morphology J:208677
abnormal long bone morphology J:208677
abnormal osteoclast physiology J:208677
abnormal trabecular bone morphology J:208677
normal craniofacial phenotype J:208677
decreased body height J:208677
decreased bone resorption J:208677
decreased circulating alkaline phosphatase level J:208677
decreased susceptibility to osteoporosis J:208677
normal homeostasis/metabolism phenotype J:208677
increased bone mineral density J:208677
increased bone trabecula number J:208677
increased compact bone thickness J:208677
increased osteoclast cell number J:208677
increased trabecular bone thickness J:208677
increased trabecular bone volume J:208677
osteopetrosis J:208677
osteosclerosis J:208677
short femur J:208677
short tibia J:208677
normal skeleton phenotype J:208677
Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H
abnormal clavicle morphology J:211773
abnormal eyelid morphology J:211773
abnormal femur morphology J:211773
abnormal fibula morphology J:211773
abnormal gait J:211773
abnormal humerus morphology J:211773
abnormal joint morphology J:211773
abnormal locomotor behavior J:211773
abnormal mandible morphology J:211773
abnormal maxilla morphology J:211773
abnormal pelvic girdle bone morphology J:211773
abnormal radius morphology J:211773
abnormal rib morphology J:211773
abnormal snout morphology J:211773
abnormal tibia morphology J:211773
abnormal tooth morphology J:211773
abnormal ulna morphology J:211773
abnormal vertebrae morphology J:211773
abnormal zygomatic bone morphology J:211773
absent teeth J:211773
decreased circulating alkaline phosphatase level J:211773
decreased eosinophil cell number J:211773
decreased lean body mass J:211773
decreased leukocyte cell number J:211773
decreased lymphocyte cell number J:211773
increased bone mineral content J:211773
increased bone mineral density J:211773
increased circulating aspartate transaminase level J:211773
increased circulating cholesterol level J:211773
increased circulating creatine kinase level J:211773
increased circulating HDL cholesterol level J:211773
increased circulating iron level J:211773
increased circulating phosphate level J:211773
increased neutrophil cell number J:211773
increased red blood cell distribution width J:211773
increased total body fat amount J:211773
short tibia J:211773
small thymus J:211773
thrombocytopenia J:211773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory