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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Slc12a6
solute carrier family 12, member 6
MGI:2135960
58 phenotypes from 9 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Pvalbtm1(cre)Arbr/Pvalb+
Slc12a6tm2.1Dlp/Slc12a6tm2.1Dlp
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
abnormal dorsal root ganglion morphology J:217087
impaired coordination J:217087
Scn10atm2(cre)Jnw/Scn10a+
Slc12a6tm2.1Dlp/Slc12a6tm2.1Dlp
involves: 129 * 129S6/SvEvTac * C57BL/6J
normal behavior/neurological phenotype J:217087
Slc12a6em1Dlp/Slc12a6em1Dlp
involves: C57BL/6J
abnormal nerve conduction J:259728
demyelination J:259728
impaired coordination J:259728
Slc12a6gaxp/Slc12a6gaxp
C3H/HeSnJ-Slc12a6gaxp/GrsrJ
abnormal axon morphology J:82451
abnormal brain morphology J:82451
abnormal myelination J:82451
ataxia J:136097
axonal dystrophy J:82451
paraparesis J:136097
weakness J:136097
Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
involves: 129S5/SvEvBrd * C57BL/6J
abnormal gait J:103485
abnormal physical strength J:103485
decreased exploration in new environment J:103485
impaired coordination J:103485
increased coping response J:103485
Slc12a6tm1.1Garo/Slc12a6tm1.1Garo
involves: 129 * C57BL/6
abnormal axon morphology J:183239
abnormal corpus callosum morphology J:183239
abnormal locomotor behavior J:183239
abnormal nervous system morphology J:183239
abnormal sciatic nerve morphology J:183239
abnormal startle reflex J:183239
axon degeneration J:183239
decreased body weight J:183239
decreased chemical nociceptive threshold J:183239
decreased corpus callosum size J:183239
demyelination J:183239
hyperactivity J:183239
impaired coordination J:183239
increased brain weight J:183239
infertility J:183239
limb grasping J:183239
Slc12a6tm1.1Tjj/Slc12a6tm1.1Tjj
Tg(Pcp2-cre)2Mpin/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
normal nervous system phenotype J:181930
Slc12a6tm1Dlp/Slc12a6+
involves: 129 * C57BL/6J
decreased exploration in new environment J:79870
decreased prepulse inhibition J:79870
normal nervous system phenotype J:79870
Slc12a6tm1Dlp/Slc12a6tm1Dlp
involves: 129 * C57BL/6J
abnormal axon morphology J:79870
abnormal limb posture J:79870
abnormal myelin sheath morphology J:79870
abnormal myelination J:79870
abnormal sciatic nerve morphology J:79870
axon degeneration J:79870
decreased exploration in new environment J:79870
decreased prepulse inhibition J:79870
demyelination J:79870
impaired coordination J:79870
impaired limb coordination J:79870
infertility J:79870
limb grasping J:79870
normal nervous system phenotype J:79870
paraparesis J:79870
Slc12a6tm1Garo/Slc12a6tm1Garo
B6.129-Slc12a6tm1Garo
no abnormal phenotype detected J:183239
Slc12a6tm1Garo/Slc12a6tm1Garo
Tg(Syn1-cre)671Jxm/0
involves: 129 * C57BL/6 * CBA
abnormal axon morphology J:183239
abnormal locomotor behavior J:183239
abnormal nervous system morphology J:183239
abnormal sciatic nerve morphology J:183239
axon degeneration J:183239
decreased body weight J:183239
decreased chemical nociceptive threshold J:183239
decreased corpus callosum size J:183239
demyelination J:183239
hyperactivity J:183239
impaired coordination J:183239
increased brain weight J:183239
infertility J:183239
limb grasping J:183239
Slc12a6tm1Tjj/Slc12a6tm1Tjj
involves: 129/Sv * C57BL/6
abnormal cell physiology J:86183
abnormal cerebellum morphology J:86183
abnormal limb posture J:86183
abnormal optic stalk morphology J:86183
abnormal sciatic nerve morphology J:86183
akinesia J:86183
axon degeneration J:86183
cochlear ganglion degeneration J:86183
cochlear hair cell degeneration J:86183
cochlear inner hair cell degeneration J:86183
cochlear outer hair cell degeneration J:86183
deafness J:86183
decreased endocochlear potential J:86183
hippocampal neuron degeneration J:86183
hypertension J:86183
increased susceptibility to pharmacologically induced seizures J:86183
limb grasping J:86183
limp posture J:86183
muscle hypertonia J:86183
neurodegeneration J:86183
organ of Corti degeneration J:86183
peripheral nervous system degeneration J:86183
sensorineural hearing loss J:86183
spinal cord degeneration J:86183
type I spiral ligament fibrocyte degeneration J:86183
type III spiral ligament fibrocyte degeneration J:86183
Slc12a6tm2.1Dlp/Slc12a6tm2.1Dlp
involves: 129S6/SvEvTac * C57BL/6J
normal no abnormal phenotype detected J:217087
Slc12a6tm2.1Dlp/Slc12a6tm2.1Dlp
Tg(Dhh-cre)1Mejr/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/N
normal behavior/neurological phenotype J:217087
Slc12a6tm2.1Dlp/Slc12a6tm2.1Dlp
Tg(Eno2-cre)39Jme/0
involves: 129S6/SvEvTac * C57BL/6J * SJL
normal behavior/neurological phenotype J:217087

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory