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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Klb
klotho beta
MGI:1932466
26 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Klbem1(IMPC)J/Klb+
C57BL/6NJ-Klbem1(IMPC)J/Mmjax
decreased grip strength J:211773
Klbem1(IMPC)J/Klbem1(IMPC)J
C57BL/6NJ-Klbem1(IMPC)J/Mmjax
abnormal embryo size J:211773
abnormal placenta size J:211773
abnormal placenta vasculature J:211773
preweaning lethality, incomplete penetrance J:211773
Klbtm1.1Akha/Klbtm1.1Akha
C57BL/6-Klbtm1.1Akha
abnormal body fat mass J:195570
abnormal circulating adiponectin level J:195570
abnormal circulating cholesterol level J:195570
abnormal circulating glucose level J:195570
abnormal circulating insulin level J:195570
abnormal circulating ketone body level J:195570
abnormal circulating leptin level J:195570
abnormal energy expenditure J:195570
decreased circulating cholesterol level J:195570
decreased circulating insulin level J:195570
decreased susceptibility to weight loss J:195570
Klbtm1.1Sakl/Klbtm1.1Sakl
Tg(Camk2a-cre)2Gsc/0
involves: 129 * C57BL/6 * FVB/N * SJL
normal growth/size/body region phenotype J:189018
normal homeostasis/metabolism phenotype J:189018
Klbtm1.1Sakl/Klbtm1.1Sakl
Tg(Fabp4-cre)1Rev/0
involves: 129 * C57BL/6 * SJL
abnormal adipose tissue physiology J:189018
abnormal glucose homeostasis J:189018
increased insulin sensitivity J:189018
Klbtm1.2Sakl/Klbtm1.2Sakl
involves: 129 * 129S4/SvJaeSor * C57BL/6
abnormal glucose homeostasis J:189018
decreased body weight J:189018
decreased circulating triglyceride level J:189018
Klbtm1Yin/Klbtm1Yin
involves: C57BL/6 * CBA
abnormal bile salt homeostasis J:100209
abnormal liver physiology J:100209
decreased body weight J:100209
small gallbladder J:100209

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory