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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pycard
PYD and CARD domain containing
MGI:1931465
25 phenotypes from 5 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Pycardtm1Ayaz/Pycardtm1Ayaz
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6J 		decreased incidence of tumors by chemical induction J:191239
decreased interleukin-1 alpha secretion J:191239
decreased interleukin-1 beta secretion J:191239
decreased interleukin-6 secretion J:191239
decreased tumor necrosis factor secretion J:191239
Pycardtm1Ayaz/Pycardtm1Ayaz
Tg(Itgax-cre)1-1Reiz/0
involves: C57BL/6 * C57BL/6J * CBA 		normal neoplasm J:191239
Pycardtm1Flv/Pycardtm1Flv
B6.129S5-Pycardtm1Flv 		abnormal gut flora balance J:173245
abnormal large intestine crypts of Lieberkuhn morphology J:173245
enlarged Peyer's patches J:173245
increased IgA level J:173245
increased IgG2c level J:173245
increased susceptibility to induced colitis J:173245
Pycardtm1Flv/Pycardtm1Flv
involves: 129S5/SvEvBrd * C57BL/6 		abnormal macrophage physiology J:113333
decreased circulating interleukin-1 beta level J:113333
decreased circulating interleukin-18 level J:113333, J:158969
decreased interleukin-1 alpha secretion J:113333
decreased interleukin-1 beta secretion J:113333
decreased NK cell number J:158969
decreased susceptibility to endotoxin shock J:113333
decreased susceptibility to type IV hypersensitivity reaction J:113333
increased susceptibility to Herpesvirales infection J:158969
Pycardtm1Nnz/Pycardtm1Nnz
involves: 129 * C57BL/6 		decreased interleukin-1 beta secretion J:129871
decreased interleukin-18 secretion J:129871
Pycardtm1Tno/Pycardtm1Tno
involves: 129S4/SvJae * C57BL/6 		decreased interferon-gamma secretion J:100807
decreased interleukin-1 beta secretion J:100807
decreased interleukin-18 secretion J:100807
decreased susceptibility to endotoxin shock J:100807
Pycardtm1Vmd/Pycardtm1Vmd
B6.129-Pycardtm1Vmd 		abnormal macrophage physiology J:160545
decreased circulating interleukin-1 beta level J:193522
decreased circulating interleukin-18 level J:193522
decreased interleukin-1 beta secretion J:160545, J:193522
decreased susceptibility to endotoxin shock J:193522
increased interferon-beta secretion J:160545
increased tumor necrosis factor secretion J:160545
Pycardtm1Vmd/Pycardtm1Vmd
involves: 129S1/Sv * 129X1/SvJ 		abnormal response to infection J:106976
decreased interleukin-1 beta secretion J:106976, J:124226
decreased interleukin-18 secretion J:106976
Pycardtm1Vmd/Pycardtm1Vmd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal neoplasm J:191239
Pycardtm1Vmd/Pycardtm1Vmd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		decreased inflammatory response J:91292
decreased interleukin-1 alpha secretion J:91292
decreased interleukin-1 beta secretion J:91292
decreased interleukin-18 secretion J:91292
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory