Pycard^tm1Tno
Targeted Allele Detail

Summary

• Symbol: Pycard^tm1Tno
• Name: PYD and CARD domain containing; targeted mutation 1, Tetsuo Noda
• MGI ID: MGI:3590154
• Synonyms: Asc^-
• Gene: Pycard Location: Chr7:127590545-127593039 bp, - strand Genetic Position: Chr7, 69.88 cM, cytoband F4
• Alliance: Pycard^tm1Tno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100807
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3 were replaced with an nLacZ cassette. Crossing with mice expressing cre in the germline removed a floxed neo included in the targeting vector. Western blot of mutant thymus, liver and spleen failed to detect protein. (J:100807)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pycard Mutation: 13 strains or lines available

References

• Original: J:100807 Yamamoto M, et al., ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells. 2004 Nov;9(11):1055-67
• All: 28 reference(s)