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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Stk4
serine/threonine kinase 4
MGI:1929004
50 phenotypes from 10 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
B6.129P2-Stk4Gt(AJ0315)Wtsi
abnormal memory T cell number J:142674
abnormal T cell differentiation J:142674
decreased CD4-positive, alpha beta T cell number J:142674
decreased CD8-positive, alpha-beta T cell number J:142674
decreased spleen white pulp amount J:142674
increased interferon-gamma secretion J:142674
increased interleukin-2 secretion J:142674
increased interleukin-4 secretion J:142674
increased T cell apoptosis J:142674
increased T cell proliferation J:142674
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
involves: 129 * C57BL/6
increased histiocytic sarcoma incidence J:153945
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
involves: 129P2/OlaHsd * C57BL/6J
normal mortality/aging J:140710
Stk4m1Btlr/Stk4m1Btlr
C57BL/6J-Stk4m1Btlr
abnormal humoral immune response J:265233
decreased B cell number J:265233
decreased CD4-positive, alpha beta T cell number J:265233
decreased CD8-positive, alpha-beta T cell number J:265233
decreased IgD level J:265233
decreased single-positive T cell number J:265233
decreased T cell number J:265233
increased IgE level J:265233
increased IgM level J:265233
increased macrophage cell number J:265233
increased neutrophil cell number J:265233
increased NK cell number J:265233
Stk4m1Mhda/Stk4+
C3HeB/FeJ-Stk4m1Mhda
no abnormal phenotype detected J:82809
Stk4m2Btlr/Stk4m2Btlr
C57BL/6J-Stk4m2Btlr
decreased B-1 B cell number J:265237
decreased B-2 B cell number J:265237
decreased CD4-positive, alpha beta T cell number J:265237
decreased CD8-positive, alpha-beta T cell number J:265237
decreased CD8-positive, naive alpha-beta T cell number J:265237
decreased IgD level J:265237
decreased single-positive T cell number J:265237
decreased T cell number J:265237
increased B-1b cell number J:265237
increased central memory CD4-positive, alpha-beta T cell number J:265237
increased central memory CD8 positive, alpha-beta T cell number J:265237
increased dendritic cell number J:265237
increased effector memory CD4-positive, alpha-beta T cell number J:265237
increased effector memory CD8-positive, alpha-beta T cell number J:265237
increased IgE level J:265237
increased macrophage cell number J:265237
increased neutrophil cell number J:265237
increased NK cell number J:265237
Stk4m3Btlr/Stk4m3Btlr
C57BL/6J-Stk4m3Btlr
decreased CD4-positive, alpha beta T cell number J:265245
decreased CD8-positive, alpha-beta T cell number J:265245
decreased single-positive T cell number J:265245
decreased T cell number J:265245
Stk4tm1.1Kina/Stk4tm1.1Kina
involves: C57BL/6
abnormal B cell physiology J:148791
abnormal dendritic cell physiology J:148791
abnormal immune system organ morphology J:148791
abnormal leukocyte adhesion J:148791
abnormal leukocyte migration J:148791
abnormal marginal zone B cell morphology J:148791
abnormal Peyer's patch germinal center morphology J:148791
abnormal Peyer's patch T cell area morphology J:148791
abnormal spleen B cell follicle morphology J:148791
abnormal T cell physiology J:148791
decreased B cell number J:148791
decreased lymphocyte cell number J:148791
decreased marginal zone B cell number J:148791
decreased myeloid dendritic cell number J:148791
decreased T cell number J:148791
increased single-positive T cell number J:148791
increased T cell proliferation J:148791
thymus hyperplasia J:148791
Stk4tm1.1Wtao/Stk4tm1.2Wtao
Tg(Lck-cre)#Zhu/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL/J
decreased CD4-positive, alpha beta T cell number J:152323
decreased CD8-positive, alpha-beta T cell number J:152323
decreased T cell number J:152323
increased single-positive T cell number J:152323
increased thymocyte number J:152323
Stk4tm1.1Yy/Stk4tm1.1Yy
involves: C57BL/6 * CBA
no abnormal phenotype detected J:156541
Stk4tm1.2Wtao/Stk4tm1.2Wtao
involves: 129S4/SvJaeSor * 129S6/SvEvTac
abnormal CD4-positive, alpha-beta T cell physiology J:152323
abnormal CD8-positive, alpha-beta T cell physiology J:152323
abnormal T cell physiology J:152323
decreased B cell number J:152323
decreased CD4-positive, alpha beta T cell number J:152323
decreased CD8-positive, alpha-beta T cell number J:152323
decreased lymphocyte cell number J:152323
increased single-positive T cell number J:152323
increased thymocyte number J:152323
Stk4tm1Dlim/Stk4tm1Dlim
Not Specified
abnormal T cell physiology J:155001
decreased T cell number J:155001

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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory