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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Tnip1
TNFAIP3 interacting protein 1
MGI:1926194
96 phenotypes from 7 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
B6.129P2-Tnip1Gt(E059E05)Wrst
prenatal lethality, incomplete penetrance J:180054
Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
involves: 129P2/OlaHsd * C57BL/6
anemia J:180054
cachexia J:180054
decreased body size J:180054
decreased body weight J:180054
decreased hemoglobin content J:180054
decreased interleukin-12 secretion J:180054
decreased interleukin-12b secretion J:180054
enlarged lymph nodes J:180054
enlarged spleen J:180054
glomerulonephritis J:180054
increased anti-double stranded DNA antibody level J:180054
increased anti-nuclear antigen antibody level J:180054
increased IgA level J:180054
increased IgG1 level J:180054
increased IgG2b level J:180054
increased IgM level J:180054
increased neutrophil cell number J:180054
increased susceptibility to systemic lupus erythematosus J:180054
increased urine protein level J:180054
lymph node hyperplasia J:180054
premature death J:180054
prenatal lethality, incomplete penetrance J:180054
spleen hyperplasia J:180054
Tnip1m1Btlr/Tnip1m1Btlr
C57BL/6J-Tnip1m1Btlr
decreased B cell number J:265175
decreased B-2 B cell number J:265175
increased anti-double stranded DNA antibody level J:265175
increased B-1a cell number J:265175
increased B-1b cell number J:265175
increased dendritic cell number J:265175
increased IgA level J:265175
increased IgE level J:265175
increased macrophage cell number J:265175
increased susceptibility to induced colitis J:265175
Tnip1tm1.1Ama/Tnip1tm1.1Ama
involves: C57BL/6J
anemia J:145539
decreased fetal size J:145539
decreased fetal weight J:145539
decreased hematocrit J:145539
increased fibroblast apoptosis J:145539
increased hepatocyte apoptosis J:145539
liver hypoplasia J:145539
pallor J:145539
perinatal lethality, incomplete penetrance J:145539
Tnip1tm1.1Pcoh/Tnip1+
involves: 129P2/OlaHsd * C57BL/6
increased anti-double stranded DNA antibody level J:176826
Tnip1tm1.1Pcoh/Tnip1tm1.1Pcoh
involves: 129P2/OlaHsd * C57BL/6
abnormal blood vessel morphology J:176826
abnormal complement pathway J:176826
abnormal effector T cell morphology J:176826
abnormal immune system morphology J:176826
abnormal intestine morphology J:176826
abnormal Peyer's patch morphology J:176826
abnormal plasma cell morphology J:176826
abnormal spleen germinal center morphology J:176826
bile duct hyperplasia J:176826
enlarged lymph nodes J:176826
enlarged spleen J:176826
glomerulonephritis J:176826
normal immune system phenotype J:176826
increased anti-double stranded DNA antibody level J:176826
increased anti-nuclear antigen antibody level J:176826
increased B cell number J:176826
increased B cell proliferation J:176826
increased fibroblast apoptosis J:176826
increased germinal center B cell number J:176826
increased granulocyte number J:176826
increased IgA level J:176826
increased IgE level J:176826
increased IgG1 level J:176826
increased IgG2a level J:176826
increased IgG2b level J:176826
increased IgG3 level J:176826
increased IgG level J:176826
increased IgM level J:176826
increased immunoglobulin level J:176826
increased interleukin-6 secretion J:176826
increased interleukin-12b secretion J:176826
increased monocyte cell number J:176826
increased plasma cell number J:176826
increased spleen red pulp amount J:176826
increased spleen weight J:176826
increased spleen white pulp amount J:176826
increased T follicular helper cell number J:176826
increased tumor necrosis factor secretion J:176826
liver fibrosis J:176826
premature death J:176826
vascular inflammation J:176826
Tnip1tm1.2Ama/Tnip1tm1.2Ama
Tg(Itgax-cre)1-1Reiz/0
involves: C57BL/6 * C57BL/6J * CBA
abnormal hematopoietic stem cell physiology J:205446
abnormal leukocyte morphology J:205446
enlarged lymph nodes J:205446
enlarged spleen J:205446
increased interleukin-6 secretion J:205446
increased interleukin-12 secretion J:205446
increased interleukin-23 secretion J:205446
increased memory T cell number J:205446
increased plasmacytoid dendritic cell number J:205446
increased tumor necrosis factor secretion J:205446
Tnip1tm1.2Pcoh/Tnip1tm1.2Pcoh
involves: 129P2/OlaHsd * C57BL/6
abnormal immune system morphology J:176826
premature death J:176826
Tnip1tm1b(EUCOMM)Hmgu/Tnip1tm1b(EUCOMM)Hmgu
C57BL/6N-Tnip1tm1b(EUCOMM)Hmgu/H
decreased circulating cholesterol level J:211773
decreased circulating fructosamine level J:211773
decreased circulating glucose level J:211773
decreased circulating HDL cholesterol level J:211773
decreased circulating iron level J:211773
decreased circulating serum albumin level J:211773
decreased circulating triglyceride level J:211773
decreased erythrocyte cell number J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
decreased lymphocyte cell number J:211773
increased basophil cell number J:211773
increased circulating alanine transaminase level J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating potassium level J:211773
increased freezing behavior J:211773
increased large unstained cell number J:211773
increased mean corpuscular hemoglobin J:211773
increased mean corpuscular hemoglobin concentration J:211773
increased mean platelet volume J:211773
increased monocyte cell number J:211773
increased red blood cell distribution width J:211773
increased spleen weight J:211773
prolonged RR interval J:211773
thrombocytopenia J:211773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory