About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Kmt2e
lysine (K)-specific methyltransferase 2E
MGI:1924825
64 phenotypes from 3 alleles in 3 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Kmt2etm1.1Hjf/Kmt2e+
B6.129P2-Kmtetm1.1Hjf
decreased thymocyte number J:145579
spleen hypoplasia J:145579
thymus hypoplasia J:145579
Kmt2etm1.1Hjf/Kmt2etm1.1Hjf
B6.129P2-Kmtetm1.1Hjf
abnormal bone marrow cell morphology/development J:145579
abnormal lymphopoiesis J:145579
abnormal myeloblast morphology/development J:145579
decreased B cell number J:145579
decreased body size J:145579
decreased body weight J:145579
decreased common myeloid progenitor cell number J:145579
decreased double-negative T cell number J:145579
decreased double-positive T cell number J:145579
decreased erythrocyte cell number J:145579
decreased hematocrit J:145579
decreased hematopoietic stem cell number J:145579
decreased leukocyte cell number J:145579
decreased macrophage cell number J:145579
decreased pre-B cell number J:145579
decreased pro-B cell number J:145579
decreased T cell number J:145579
decreased thymocyte number J:145579
globozoospermia J:145579
normal immune system phenotype J:145579
increased mortality induced by gamma-irradiation J:145579
male infertility J:145579
neonatal lethality, incomplete penetrance J:145579
postnatal lethality, incomplete penetrance J:145579
reduced female fertility J:145579
small lymph nodes J:145579
small spleen J:145579
small thymus J:145579
spleen hypoplasia J:145579
thrombocytopenia J:145579
thymus hypoplasia J:145579
Kmt2etm1Apa/Kmt2etm1Apa
129S6/SvEvTac-Kmt2etm1Apa
abnormal acrosome morphology J:181000
abnormal cauda epididymis morphology J:181000
abnormal definitive hematopoiesis J:145445
abnormal granulocyte differentiation J:145445
abnormal neutrophil differentiation J:145445
abnormal neutrophil physiology J:145445
abnormal sperm head morphology J:181000
abnormal sperm nucleus morphology J:181000
abnormal spermatogenesis J:181000
abnormal spermiogenesis J:181000
asthenozoospermia J:181000
blepharitis J:145445
decreased body weight J:145445
decreased hematocrit J:145445
decreased hemoglobin content J:145445
decreased sperm progressive motility J:181000
decreased total body fat amount J:145445
detached acrosome J:181000
dilated seminal vesicle J:145445
normal homeostasis/metabolism phenotype J:181000
impaired fertilization J:181000
impaired sperm penetration of zona pellucida J:181000
increased hemoglobin concentration distribution width J:145445
increased susceptibility to bacterial infection J:145445
lethality during fetal growth through weaning, incomplete penetrance J:145445
low mean erythrocyte cell number J:145445
male infertility J:145445, J:181000
normal reproductive system phenotype J:181000
Kmt2etm1Nik/Kmt2etm1Nik
B6.Cg-Kmtetm1Nik
abnormal definitive hematopoiesis J:145449
abnormal hematopoietic stem cell morphology J:145449
decreased hematopoietic stem cell number J:145449
decreased NK cell number J:145449
decreased NK T cell number J:145449
normal hematopoietic system phenotype J:145449
increased hematopoietic stem cell number J:145449
increased neutrophil cell number J:145449
neonatal lethality, incomplete penetrance J:145449
postnatal growth retardation J:145449
postnatal lethality, complete penetrance J:145449

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory