Cyfip2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cyfip2
cytoplasmic FMR1 interacting protein 2
MGI:1924134

20 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cyfip2^M1N/Cyfip2⁺ (C57BL/6N x C57BL/6J)F1	impaired behavioral response to cocaine	J:203183
Cyfip2^M1N/Cyfip2^M1N C57BL/6N	abnormal dendritic spine morphology	J:203183
	decreased miniature excitatory postsynaptic current frequency	J:203183
	impaired behavioral response to cocaine	J:203183
Cyfip2^M1N/Cyfip2^{tm1a(EUCOMM)Wtsi} C57BL/6N-Cyfip2^M1N/Cyfip2^{tm1a(EUCOMM)Wtsi}	enhanced behavioral response to cocaine	J:203183
Cyfip2^{tm1(KOMP)Vlcg}/Cyfip2⁺ involves: C57BL/6J * C57BL/6NTac	abnormal anxiety-related response	J:219363
	abnormal dendritic spine morphology	J:219363
	decreased startle reflex	J:219363
	hyperactivity	J:219363
	increased prepulse inhibition	J:219363
	normal nervous system phenotype	J:219363
Cyfip2^{tm1(KOMP)Vlcg}/Cyfip2^{tm1(KOMP)Vlcg} involves: C57BL/6J * C57BL/6NTac	postnatal lethality, complete penetrance	J:219363
Cyfip2^{tm1a(EUCOMM)Wtsi}/Cyfip2^{tm1a(EUCOMM)Wtsi} C57BL/6N-Cyfip2^{tm1a(EUCOMM)Wtsi}	neonatal lethality, complete penetrance	J:203183
Cyfip2^{tm1a(EUCOMM)Wtsi}/Cyfip2^{tm1a(EUCOMM)Wtsi} C57BL/6N-Cyfip2^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal hindbrain morphology	J:239583
	abnormal inferior vena cava valve morphology	J:239583
	bicuspid aortic valve	J:239583
	bifid ureter	J:239583
	dilated ureter	J:239583
	duplex kidney	J:239583
	no abnormal phenotype detected	J:239583
	preweaning lethality, complete penetrance	J:211773
	subcutaneous edema	J:239583

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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