Fbxw8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fbxw8
F-box and WD-40 domain protein 8
MGI:1923041

28 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fbxw8^{Gt(RRT057)Byg}/Fbxw8^{Gt(RRT057)Byg} involves: 129P2/OlaHsd * C57BL/6	abnormal brain size	J:130238
	atelectasis	J:130238
	cyanosis	J:130238
	decreased body weight	J:130238
	decreased embryo size	J:130238
	decreased fetal size	J:130238
	decreased placenta weight	J:130238
	decreased survivor rate	J:130238
	neonatal lethality, incomplete penetrance	J:130238
	respiratory distress	J:130238
	normal skeleton phenotype	J:130238
	slow postnatal weight gain	J:130238
Fbxw8^{tm1b(EUCOMM)Hmgu}/Fbxw8⁺ C57BL/6N-Fbxw8^{tm1b(EUCOMM)Hmgu}/Nju	decreased lymphocyte cell number	J:211773
	increased basophil cell number	J:211773
	increased blood urea nitrogen level	J:211773
	increased circulating creatinine level	J:211773
	increased eosinophil cell number	J:211773
	increased neutrophil cell number	J:211773
Fbxw8^{tm1b(EUCOMM)Hmgu}/Fbxw8^{tm1b(EUCOMM)Hmgu} C57BL/6N-Fbxw8^{tm1b(EUCOMM)Hmgu}/Nju	preweaning lethality, incomplete penetrance	J:211773
Fbxw8^tm1Kei/Fbxw8^tm1Kei involves: C57BL/6	abnormal placenta labyrinth morphology	J:111403
	abnormal placenta morphology	J:111403
	abnormal placental labyrinth vasculature morphology	J:111403
	abnormal spongiotrophoblast layer morphology	J:111403
	decreased embryo size	J:111403
	embryonic growth retardation	J:111403
	embryonic lethality during organogenesis, incomplete penetrance	J:111403
	lethality throughout fetal growth and development, incomplete penetrance	J:111403
	normal respiratory system phenotype	J:111403
Fbxw8^tm1Kei/Fbxw8^tm1Kei Not Specified	normal cellular phenotype	J:183656

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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