Tmco1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tmco1
transmembrane and coiled-coil domains 1
MGI:1921173

46 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tmco1^em1(IMPC)J/Tmco1⁺ C57BL/6NJ-Tmco1^em1(IMPC)J/J	corneal opacity	J:211773
Tmco1^em1(IMPC)J/Tmco1⁺ C57BL/6NJ-Tmco1^em1(IMPC)J/J	increased leukocyte cell number	J:211773
Tmco1^em1(IMPC)J/Tmco1^em1(IMPC)J C57BL/6NJ-Tmco1^em1(IMPC)J/J	female infertility	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Tmco1^em1Smoc/Tmco1^em1Smoc C57BL/6J-Tmco1^em1Smoc	abnormal calcium ion homeostasis	J:233671
	abnormal cranium morphology	J:233671
	abnormal osteoblast physiology	J:233671
	abnormal ovarian follicle morphology	J:268917
	ataxia	J:233671
	decreased body size	J:233671
	decreased body weight	J:233671
	decreased survivor rate	J:233671
	delayed bone ossification	J:233671
	enlarged brain ventricles	J:233671
	flat face	J:233671
	impaired coordination	J:233671
	impaired spatial learning	J:233671
	megacephaly	J:233671
	postnatal growth retardation	J:233671
	prenatal lethality, incomplete penetrance	J:233671
	short frontal bone	J:233671
	short nasal bone	J:233671
	short snout	J:233671
	wide cranial sutures	J:233671
Tmco1^tm1Tsta/Tmco1^tm1Tsta B6.Cg-Tmco1^tm1Tsta	abnormal calcium ion homeostasis	J:268917
	abnormal ovary morphology	J:268917
	absent corpus luteum	J:268917
	absent ovarian follicles	J:268917
	decreased body weight	J:268917
	decreased circulating estradiol level	J:268917
	decreased litter size	J:268917
	decreased ovary weight	J:268917
	decreased primary ovarian follicle number	J:268917
	decreased primordial ovarian follicle number	J:268917
	decreased secondary ovarian follicle number	J:268917
	decreased superovulation rate	J:268917
	normal homeostasis/metabolism phenotype	J:268917
	impaired ovarian folliculogenesis	J:268917
	increased atretic ovarian follicle number	J:268917
	increased circulating follicle stimulating hormone level	J:268917
	increased circulating luteinizing hormone level	J:268917
	increased endoplasmic reticulum stress	J:268917
	increased granulosa cell apoptosis	J:268917
	oocyte degeneration	J:268917
	oxidative stress	J:268917
	premature ovarian failure	J:268917
	reduced female fertility	J:268917
	small ovary	J:268917

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23